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Chronic inflammation in the etiology of disease across the life span

Nature medicine, 2019-12, Vol.25 (12), p.1822-1832 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-019-0675-0 ;PMID: 31806905

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Title:
Chronic inflammation in the etiology of disease across the life span
Author: Furman, David ; Campisi, Judith ; Verdin, Eric ; Carrera-Bastos, Pedro ; Targ, Sasha ; Franceschi, Claudio ; Ferrucci, Luigi ; Gilroy, Derek W ; Fasano, Alessio ; Miller, Gary W ; Miller, Andrew H ; Mantovani, Alberto ; Weyand, Cornelia M ; Barzilai, Nir ; Goronzy, Jorg J ; Rando, Thomas A ; Effros, Rita B ; Lucia, Alejandro ; Kleinstreuer, Nicole ; Slavich, George M
Subjects: Autoimmune Diseases - etiology ; Autoimmune Diseases - physiopathology ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Chronic Disease - epidemiology ; Chronic diseases ; Diabetes mellitus ; Diabetes Mellitus - etiology ; Diabetes Mellitus - physiopathology ; Etiology ; Fatty liver ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Health risk assessment ; Health Sciences ; Humans ; Hälsovetenskap ; Infections ; Inflammation ; Inflammation - complications ; Inflammation - epidemiology ; Inflammation - physiopathology ; Kidney diseases ; Life span ; Life Style ; Liver diseases ; Longevity - genetics ; Longevity - physiology ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Neoplasms - etiology ; Neoplasms - physiopathology ; Neurodegenerative diseases ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - physiopathology ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - physiopathology ; Patient outcomes ; Phenotypes ; Psychological stress ; Public Health, Global Health, Social Medicine and Epidemiology ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - physiopathology ; Risk analysis ; Risk Factors ; Toxicants
Is Part Of: Nature medicine, 2019-12, Vol.25 (12), p.1822-1832
Description: Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1078-8956
EISSN: 1546-170X
DOI: 10.1038/s41591-019-0675-0
PMID: 31806905
Source: MEDLINE
ProQuest Central

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Chronic inflammation in the etiology of disease across the life span

COPYRIGHT 2019 Nature Publishing Group ;COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-019-0675-0 ;PMID: 31806905

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