Language:

Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

Aging cell, 2016-10, Vol.15 (5), p.811-824 [Peer Reviewed Journal]

2016 The Authors. published by the Anatomical Society and John Wiley & Sons Ltd. ;2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. ;COPYRIGHT 2016 John Wiley & Sons, Inc. ;Copyright © 2016 The Anatomical Society and John Wiley & Sons Ltd ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1474-9718 ;ISSN: 1474-9726 ;EISSN: 1474-9726 ;DOI: 10.1111/acel.12490 ;PMID: 27329260

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits
Author: Teumer, Alexander ; Qi, Qibin ; Nethander, Maria ; Aschard, Hugues ; Bandinelli, Stefania ; Beekman, Marian ; Berndt, Sonja I. ; Bidlingmaier, Martin ; Broer, Linda ; Cappola, Anne ; Ceda, Gian Paolo ; Chanock, Stephen ; Chen, Ming‐Huei ; Chen, Tai C. ; Chen, Yii‐Der Ida ; Chung, Jonathan ; Del Greco Miglianico, Fabiola ; Eriksson, Joel ; Ferrucci, Luigi ; Friedrich, Nele ; Gnewuch, Carsten ; Goodarzi, Mark O. ; Grarup, Niels ; Guo, Tingwei ; Hammer, Elke ; Hayes, Richard B. ; Hicks, Andrew A. ; Hofman, Albert ; Houwing‐Duistermaat, Jeanine J. ; Hu, Frank ; Hunter, David J. ; Husemoen, Lise L. ; Isaacs, Aaron ; Jacobs, Kevin B. ; Janssen, Joop A. M. J. L. ; Jansson, John‐Olov ; Jehmlich, Nico ; Johnson, Simon ; Juul, Anders ; Karlsson, Magnus ; Kilpelainen, Tuomas O. ; Kovacs, Peter ; Kraft, Peter ; Li, Chao ; Linneberg, Allan ; Liu, Yongmei ; Loos, Ruth J. F. ; Lorentzon, Mattias ; Lu, Yingchang ; Maggio, Marcello ; Magi, Reedik ; Meigs, James ; Mellström, Dan ; Nauck, Matthias ; Newman, Anne B. ; Pollak, Michael N. ; Pramstaller, Peter P. ; Prokopenko, Inga ; Psaty, Bruce M. ; Reincke, Martin ; Rimm, Eric B. ; Rotter, Jerome I. ; Saint Pierre, Aude ; Schurmann, Claudia ; Seshadri, Sudha ; Sjögren, Klara ; Slagboom, P. Eline ; Strickler, Howard D. ; Stumvoll, Michael ; Suh, Yousin ; Sun, Qi ; Zhang, Cuilin ; Svensson, Johan ; Tanaka, Toshiko ; Tare, Archana ; Tönjes, Anke ; Uh, Hae‐Won ; van Duijn, Cornelia M. ; Heemst, Diana ; Vandenput, Liesbeth ; Vasan, Ramachandran S. ; Völker, Uwe ; Willems, Sara M. ; Ohlsson, Claes ; Wallaschofski, Henri ; Kaplan, Robert C.
Subjects: Adult ; Aging ; Aging - blood ; Aging - genetics ; Analysis ; Applications ; Basic Medicine ; Bioinformatics ; Cancer ; Computer Science ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; Female ; Gene expression ; Gene Expression Regulation ; Genetic research ; Genetics ; Genome-Wide Association Study ; Genomes ; genomewide association study ; growth hormone axis ; Human genetics ; Humans ; IGF-I ; IGFBP-3 ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor Binding Protein 3 - genetics ; Insulin-Like Growth Factor I ; Insulin-Like Growth Factor I - genetics ; Life Sciences ; longevity ; Male ; Medical and Health Sciences ; Medical Biotechnology ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk bioteknologi ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Metabolome ; Metabolome - genetics ; Methodology ; Oncology, Experimental ; Original ; Protein binding ; Proteins ; Quantitative Trait Loci ; Quantitative Trait Loci - genetics ; Quantitative Trait, Heritable ; Regulatory Sequences, Nucleic Acid ; Regulatory Sequences, Nucleic Acid - genetics ; Santé publique et épidémiologie ; Single nucleotide polymorphisms ; Statistics ; Type 2 diabetes
Is Part Of: Aging cell, 2016-10, Vol.15 (5), p.811-824
Description: Summary The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF‐I and IGFBP‐3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype–phenotype associations between men and women, were found only for associations of IGFBP‐3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF‐I and IGFBP‐3 concentrations. The IGF‐I‐decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90 years. The known longevity‐associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF‐I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF‐I‐ and IGFBP‐3‐associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF‐I and IGFBP‐3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity‐associated loci.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1474-9718
ISSN: 1474-9726
EISSN: 1474-9726
DOI: 10.1111/acel.12490
PMID: 27329260
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
SWEPUB Freely available online
Wiley Blackwell Open Access Titles
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

Searching Remote Databases, Please Wait