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Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

The New England journal of medicine, 2021-01, Vol.384 (2), p.105-116 [Peer Reviewed Journal]

Copyright © 2020 Massachusetts Medical Society. All rights reserved. ;Copyright © 2020 Massachusetts Medical Society. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa2025797 ;PMID: 33185990

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Title:
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
Author: Teerlink, John R ; Diaz, Rafael ; Felker, G. Michael ; McMurray, John J.V ; Metra, Marco ; Solomon, Scott D ; Adams, Kirkwood F ; Anand, Inder ; Arias-Mendoza, Alexandra ; Biering-Sørensen, Tor ; Böhm, Michael ; Bonderman, Diana ; Cleland, John G.F ; Corbalan, Ramon ; Crespo-Leiro, Maria G ; Dahlström, Ulf ; Echeverria, Luis E ; Fang, James C ; Filippatos, Gerasimos ; Fonseca, Cândida ; Goncalvesova, Eva ; Goudev, Assen R ; Howlett, Jonathan G ; Lanfear, David E ; Li, Jing ; Lund, Mayanna ; Macdonald, Peter ; Mareev, Viacheslav ; Momomura, Shin-ichi ; O’Meara, Eileen ; Parkhomenko, Alexander ; Ponikowski, Piotr ; Ramires, Felix J.A ; Serpytis, Pranas ; Sliwa, Karen ; Spinar, Jindrich ; Suter, Thomas M ; Tomcsanyi, Janos ; Vandekerckhove, Hans ; Vinereanu, Dragos ; Voors, Adriaan A ; Yilmaz, Mehmet B ; Zannad, Faiez ; Sharpsten, Lucie ; Legg, Jason C ; Varin, Claire ; Honarpour, Narimon ; Abbasi, Siddique A ; Malik, Fady I ; Kurtz, Christopher E
Subjects: Aged ; Aged, 80 and over ; Angina pectoris ; Arrhythmia ; Brain natriuretic peptide ; Calcium-binding protein ; Cardiac Myosins - drug effects ; Cardiac Myosins - metabolism ; Cardiac output ; Cardiology and cardiovascular system ; Cardiomyopathy ; Cardiotonic Agents - adverse effects ; Cardiotonic Agents - pharmacology ; Cardiotonic Agents - therapeutic use ; Cardiovascular agents ; Cardiovascular Diseases - mortality ; Clinical medicine ; Congestive heart failure ; Control ; Design ; Drug therapy ; Ejection fraction ; Female ; Heart attacks ; Heart failure ; Heart Failure, Systolic - drug therapy ; Heart Failure, Systolic - metabolism ; Heart Failure, Systolic - physiopathology ; Hospitalization ; Human health and pathology ; Humans ; Ischemia ; Life Sciences ; Male ; Middle Aged ; Myocardial Contraction - drug effects ; Myosin ; Observations ; Patient outcomes ; Patient safety ; Peptides ; Physiological aspects ; Placebos ; Statistical analysis ; Stroke Volume ; Testing ; Troponin ; Troponin I ; Urea - adverse effects ; Urea - analogs & derivatives ; Urea - pharmacology ; Urea - therapeutic use ; Ventricle
Is Part Of: The New England journal of medicine, 2021-01, Vol.384 (2), p.105-116
Description: Among patients with heart failure and a reduced ejection fraction, those who received the cardiac myosin activator omecamtiv mecarbil had a lower incidence of a composite of heart-failure events or cardiovascular death at a median of 22 months than those who received placebo.
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
ISSN: 1533-4406
EISSN: 1533-4406
DOI: 10.1056/NEJMoa2025797
PMID: 33185990
Source: ProQuest One Psychology
Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
ProQuest Central

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Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

Copyright © 2020 Massachusetts Medical Society. All rights reserved. ;Copyright © 2020 Massachusetts Medical Society. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa2025797 ;PMID: 33185990

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