skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

A meta-analysis on the association of genetic polymorphism of the angiotensin-converting enzyme and coronary artery disease in the chinese population

Revista da Associacao Medica Brasileira (1992), 2019-06, Vol.65 (6), p.923-929 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ;ISSN: 0104-4230 ;ISSN: 1806-9282 ;EISSN: 1806-9282 ;DOI: 10.1590/1806-9282.65.6.923 ;PMID: 31340327

Digital Resources/Online E-Resources

Citations Cited by
  • Title:
    A meta-analysis on the association of genetic polymorphism of the angiotensin-converting enzyme and coronary artery disease in the chinese population
  • Author: Zhang, Yongjun ; Yang, Tao ; Zhou, Wenjiao ; Huang, Yuee
  • Subjects: China - ethnology ; Coronary Artery Disease - ethnology ; Coronary Artery Disease - genetics ; Genetic Association Studies ; Humans ; MEDICINE, GENERAL & INTERNAL ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Risk Factors
  • Is Part Of: Revista da Associacao Medica Brasileira (1992), 2019-06, Vol.65 (6), p.923-929
  • Description: To investigate the association between genotype insertion or deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and susceptibility to coronary artery disease (CAD) in Chinese Han population. We conducted a comprehensive search for the OR value of contrast between the group of genotype insertion or deletion polymorphism of the ACE and the group of CAD as an effective index. A meta-analysis (Stata 12.0) was used to test the heterogeneity of the results, combine the values for effect, conduct sensitivity analysis, and basic evaluation. A total of 638 studies were found on the association between polymorphisms of the angiotensin-converting enzyme gene and CAD, of which 44 studies met the inclusion criteria. In total, our study included 5619 cases and 4865 controls. The heterogeneity test of each study (P < 0.001) was carried out using a random effect model. The OR value of DD/ID+II was 1.95, 95% confidence interval (95%CI) (1.66-2.29). The OR value of II/DI+DD was 0.63, 95%CI (0.55-0.72). The funnel figure is basically symmetrical and the results of the sensitivity analysis were stable. The DD genotype of the angiotensin converting enzyme gene may be a weaker risk factor for CAD in the Chinese Han population.
  • Publisher: Brazil: Associação Médica Brasileira
  • Language: English;Portuguese
  • Identifier: ISSN: 0104-4230
    ISSN: 1806-9282
    EISSN: 1806-9282
    DOI: 10.1590/1806-9282.65.6.923
    PMID: 31340327
  • Source: SciELO
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait