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The usefulness of systemic inflammatory markers as diagnostic indicators of the pathogenesis of diabetic macular edema

Arquivos brasileiros de oftalmologia, 2020-08, Vol.83 (4), p.299-304 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0004-2749 ;ISSN: 1678-2925 ;EISSN: 1678-2925 ;DOI: 10.5935/0004-2749.20200051 ;PMID: 32756784

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  • Title:
    The usefulness of systemic inflammatory markers as diagnostic indicators of the pathogenesis of diabetic macular edema
  • Author: Ilhan, Cagri ; Citirik, Mehmet ; Uzel, Mehmet Murat ; Kiziltoprak, Hasan ; Tekin, Kemal
  • Subjects: Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Humans ; Lymphocytes ; Macular Edema - diagnosis ; Macular Edema - etiology ; Mean Platelet Volume ; Neutrophils ; OPHTHALMOLOGY
  • Is Part Of: Arquivos brasileiros de oftalmologia, 2020-08, Vol.83 (4), p.299-304
  • Description: To investigate the usefulness of systemic inflammatory markers [i.e., white blood cell and platelet counts, mean platelet volume, and their ratios] as diagnostic markers of the pathogenesis of diabetic macular edema. The study cohort included 80 diabetic macular edema patients (40 with diabetic retinopathy and 40 without) and 40 healthy age- and sex-matched controls. Neutrophil, lymphocyte, monocyte, and platelet counts, and the mean platelet volume were determined from peripheral blood samples, and the monocyte/lymphocyte, platelet/lymphocyte, and mean platelet volume/lymphocyte, and neutrophil/lymphocyte ratios were calculated and compared among groups. The mean neutrophil/lymphocyte ratio of the diabetic macular edema and non-diabetic macular edema groups was higher than that of the control group, and the value of the diabetic macular edema group was higher than that of the non-diabetic macular edema group (p<0.001 in diabetic macular edema vs. control, p=0.04 in non-diabetic macular edema vs. control, and p=0.03 in diabetic macular edema vs. non-diabetic macular edema). A neutrophil/lymphocyte cutoff value of ≥2.26 was identified as an indicator of the pathogenesis of diabetic macular edema with a sensitivity of 85% and specificity of 74%. The mean platelet volume of the diabetic macular edema group was higher than those of the non-diabetic macular edema and control groups, while those of the non-diabetic macular edema and control groups were similar (diabetic macular edema vs. non-diabetic macular edema, p=0.08; diabetic macular edema vs. control, p=0.02; and non- diabetic macular edema vs. control, p=0.78). All other parameters were similar between groups (all p>0.05). The neutrophil/lymphocyte ratio and mean platelet volume of the diabetic macular edema group were higher than those of the non-diabetic macular edema and control groups. A neutrophil/lymphocyte ratio cutoff value of ≥2.26 was identified as an indicator of the pathogenesis of diabetic macular edema with high sensitivity and specificity. Moreover, the neutrophil/ lymphocyte ratio of the non-diabetic macular edema group was higher than that of the control group.
  • Publisher: Brazil: Conselho Brasileiro de Oftalmologia
  • Language: English;Portuguese
  • Identifier: ISSN: 0004-2749
    ISSN: 1678-2925
    EISSN: 1678-2925
    DOI: 10.5935/0004-2749.20200051
    PMID: 32756784
  • Source: IngentaConnect Free/Open Access Journals
    SciELO
    GFMER Free Medical Journals
    MEDLINE
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