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The human genetic epidemiology of COVID-19

Nature reviews. Genetics, 2022-09, Vol.23 (9), p.533-546 [Peer Reviewed Journal]

2022. Springer Nature Limited. ;Springer Nature Limited 2022. ;Springer Nature Limited 2022 ;ISSN: 1471-0056 ;EISSN: 1471-0064 ;DOI: 10.1038/s41576-022-00478-5 ;PMID: 35501396

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  • Title:
    The human genetic epidemiology of COVID-19
  • Author: Niemi, Mari E K ; Daly, Mark J ; Ganna, Andrea
  • Subjects: Coronaviruses ; COVID-19 ; Disease ; Epidemiology ; Genetic variance ; Genomics ; Infectious diseases ; Phenotypes ; Review ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination
  • Is Part Of: Nature reviews. Genetics, 2022-09, Vol.23 (9), p.533-546
  • Description: Human genetics can inform the biology and epidemiology of coronavirus disease 2019 (COVID-19) by pinpointing causal mechanisms that explain why some individuals become more severely affected by the disease upon infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Large-scale genetic association studies, encompassing both rare and common genetic variants, have used different study designs and multiple disease phenotype definitions to identify several genomic regions associated with COVID-19. Along with a multitude of follow-up studies, these findings have increased our understanding of disease aetiology and provided routes for management of COVID-19. Important emergent opportunities include the clinical translatability of genetic risk prediction, the repurposing of existing drugs, exploration of variable host effects of different viral strains, study of inter-individual variability in vaccination response and understanding the long-term consequences of SARS-CoV-2 infection. Beyond the current pandemic, these transferrable opportunities are likely to affect the study of many infectious diseases.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1471-0056
    EISSN: 1471-0064
    DOI: 10.1038/s41576-022-00478-5
    PMID: 35501396
  • Source: ProQuest Central
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