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The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging

Human brain mapping, 2022-04, Vol.43 (6), p.1997-2010 [Peer Reviewed Journal]

2022 The Authors. published by Wiley Periodicals LLC. ;2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. ;2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1065-9471 ;EISSN: 1097-0193 ;DOI: 10.1002/hbm.25769 ;PMID: 35112422

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Title:
The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging
Author: Ryan, Meghann C. ; Hong, L. Elliot ; Hatch, Kathryn S. ; Gao, Si ; Chen, Shuo ; Haerian, Krystl ; Wang, Jingtao ; Goldwaser, Eric L. ; Du, Xiaoming ; Adhikari, Bhim M. ; Bruce, Heather ; Hare, Stephanie ; Kvarta, Mark D. ; Jahanshad, Neda ; Nichols, Thomas E. ; Thompson, Paul M. ; Kochunov, Peter
Subjects: accelerated brain aging ; Age ; Aged ; Aging ; Alcohol ; Biobanks ; Bipolar disorder ; Brain ; Brain - diagnostic imaging ; cardio‐metabolic disorders ; Cognitive ability ; Dementia ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - epidemiology ; Diabetes ; Humans ; Hypertension ; Illnesses ; Machine learning ; Medical imaging ; Mental depression ; Mental disorders ; Mental Disorders - epidemiology ; Metabolic Diseases - complications ; Metabolic Diseases - epidemiology ; Metabolic disorders ; Middle Aged ; MRI ; Neuroleptics ; quantile regression index ; Risk factors ; Schizophrenia ; severe mental illness ; Smoking ; Software ; Substantia alba ; UK Biobank
Is Part Of: Human brain mapping, 2022-04, Vol.43 (6), p.1997-2010
Description: Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD) elevate accelerated brain aging risks. Cardio‐metabolic disorders (CMD) are common comorbidities in SMI and negatively impact brain health. We validated a linear quantile regression index (QRI) approach against the machine learning “BrainAge” index in an independent SSD cohort (N = 206). We tested the direct and additive effects of SMI and CMD effects on accelerated brain aging in the N = 1,618 (604 M/1,014 F, average age = 63.53 ± 7.38) subjects with SMI and N = 11,849 (5,719 M/6,130 F; 64.42 ± 7.38) controls from the UK Biobank. Subjects were subdivided based on diagnostic status: SMI+/CMD+ (N = 665), SMI+/CMD− (N = 964), SMI−/CMD+ (N = 3,765), SMI−/CMD− (N = 8,083). SMI (F = 40.47, p = 2.06 × 10−10) and CMD (F = 24.69, p = 6.82 × 10−7) significantly, independently impacted whole‐brain QRI in SMI+. SSD had the largest effect (Cohen’s d = 1.42) then BD (d = 0.55), and MDD (d = 0.15). Hypertension had a significant effect on SMI+ (d = 0.19) and SMI− (d = 0.14). SMI effects were direct, independent of MD, and remained significant after correcting for effects of antipsychotic medications. Whole‐brain QRI was significantly (p < 10−16) associated with the volume of white matter hyperintensities (WMH). However, WMH did not show significant association with SMI and was driven by CMD, chiefly hypertension (p < 10−16). We used a simple and robust index, QRI, the demonstrate additive effect of SMI and CMD on accelerated brain aging. We showed a greater effect of psychiatric illnesses on QRI compared to cardio‐metabolic illness. Our findings suggest that subjects with SMI should be among the targets for interventions to protect against age‐related cognitive decline. Severe mental illnesses including major depressive disorder, bipolar disorder, and schizophrenia spectrum disorder elevate accelerated brain aging risks; cardio‐metabolic disorders are common comorbidities and can negatively impact brain health. We used a simple and robust index, QRI, the demonstrate additive effect of SMI and CMD on accelerated brain aging. We showed a greater effect of psychiatric illnesses on QRI compared to cardio‐metabolic illness.
Publisher: Hoboken, USA: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1065-9471
EISSN: 1097-0193
DOI: 10.1002/hbm.25769
PMID: 35112422
Source: Journals@Ovid Open Access Journal Collection Rolling
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PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging

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