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New Aspects of Diabetes Research and Therapeutic Development

Pharmacological reviews, 2021-07, Vol.73 (3), p.1001-1015 [Peer Reviewed Journal]

U.S. Government work not protected by U.S. copyright. 2021 ;ISSN: 0031-6997 ;EISSN: 1521-0081 ;DOI: 10.1124/pharmrev.120.000160 ;PMID: 34193595

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  • Title:
    New Aspects of Diabetes Research and Therapeutic Development
  • Author: Satin, Leslie S. ; Soleimanpour, Scott A. ; Walker, Emily M.
  • Isom, Lori
  • Subjects: Review
  • Is Part Of: Pharmacological reviews, 2021-07, Vol.73 (3), p.1001-1015
  • Description: Both type 1 and type 2 diabetes mellitus are advancing at exponential rates, placing significant burdens on health care networks worldwide. Although traditional pharmacologic therapies such as insulin and oral antidiabetic stalwarts like metformin and the sulfonylureas continue to be used, newer drugs are now on the market targeting novel blood glucose–lowering pathways. Furthermore, exciting new developments in the understanding of beta cell and islet biology are driving the potential for treatments targeting incretin action, islet transplantation with new methods for immunologic protection, and the generation of functional beta cells from stem cells. Here we discuss the mechanistic details underlying past, present, and future diabetes therapies and evaluate their potential to treat and possibly reverse type 1 and 2 diabetes in humans.
  • Publisher: Bethesda, MD: The American Society for Pharmacology and Experimental Therapeutics
  • Language: English
  • Identifier: ISSN: 0031-6997
    EISSN: 1521-0081
    DOI: 10.1124/pharmrev.120.000160
    PMID: 34193595
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    Alma/SFX Local Collection
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