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A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development

BMB reports, 2021-06, Vol.54 (6), p.285-294 [Peer Reviewed Journal]

Copyright © 2021 by the The Korean Society for Biochemistry and Molecular Biology 2021 ;ISSN: 1976-6696 ;EISSN: 1976-670X ;DOI: 10.5483/BMBRep.2021.54.6.020 ;PMID: 33691907

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  • Title:
    A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
  • Author: Cha, Boksik ; Moon, Sungjin ; Kim, Wantae
  • Subjects: Invited Mini Review
  • Is Part Of: BMB reports, 2021-06, Vol.54 (6), p.285-294
  • Description: The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.
  • Publisher: Korean Society for Biochemistry and Molecular Biology
  • Language: English
  • Identifier: ISSN: 1976-6696
    EISSN: 1976-670X
    DOI: 10.5483/BMBRep.2021.54.6.020
    PMID: 33691907
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
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