skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding

Biomedical optics express, 2021-06, Vol.12 (6), p.3729-3742 [Peer Reviewed Journal]

2021 Optical Society of America under the terms of the 2021 Optical Society of America ;ISSN: 2156-7085 ;EISSN: 2156-7085 ;DOI: 10.1364/BOE.426928 ;PMID: 34221691

Full text available

Citations Cited by
  • Title:
    0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding
  • Author: Shang, Sen ; Wu, XingJuan ; Zhang, Qi ; Zhao, Jiping ; Hu, Erling ; Wang, Leilei ; Lu, Xiaoyun
  • Is Part Of: Biomedical optics express, 2021-06, Vol.12 (6), p.3729-3742
  • Description: In recent years, many studies have been conducted to investigate the influence of terahertz (THz) radiation on the gene expression in various cell types, but the underling molecular mechanism has not yet been fully revealed. In this study, we explored the effects of 0.1 THz radiation on the gene expression in primary neuron cells through RNA-seq analysis. 111 up-regulated and 54 down-regulated genes were identified. Several biomolecule binding related categories such as “long-chain fatty acid binding”, “tropomyosin binding”, “BMP receptor binding”, as well as “GTPase binding” and “phospholipid binding” were enriched by GO analysis. Moreover, the GSEA analysis indicated that genes encoding protein biosynthetic machinery ribosome were up-regulated by 0.1 THz irradiation. In addition, we demonstrated that the binding efficiency of a transcription factor (TF) AP-1 with its transcription factor binding site (TFBS) in DNA was reduced by THz irradiation, which suggested that THz irradiation might affect the interaction between TFs with DNA and consequently regulate the gene expression. Our results provide new insights into the biological effects of terahertz irradiation.
  • Publisher: Optical Society of America
  • Language: English
  • Identifier: ISSN: 2156-7085
    EISSN: 2156-7085
    DOI: 10.1364/BOE.426928
    PMID: 34221691
  • Source: Directory of Open Access Scholarly Resources (ROAD)
    Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait