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The essential elements of Alzheimer’s disease

The Journal of biological chemistry, 2021-01, Vol.296, p.100105-100105, Article 100105 [Peer Reviewed Journal]

2020 The Authors ;Published under license by The American Society for Biochemistry and Molecular Biology, Inc. ;2020 The Authors 2020 ;ISSN: 0021-9258 ;EISSN: 1083-351X ;DOI: 10.1074/jbc.REV120.008207 ;PMID: 33219130

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  • Title:
    The essential elements of Alzheimer’s disease
  • Author: Lei, Peng ; Ayton, Scott ; Bush, Ashley I.
  • Subjects: Alzheimer’s disease ; clioquinol ; copper ; ferroptosis ; iron ; JBC Reviews ; PBT2 ; selenium ; zinc
  • Is Part Of: The Journal of biological chemistry, 2021-01, Vol.296, p.100105-100105, Article 100105
  • Description: Treatments for Alzheimer’s disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are several other neurochemical abnormalities that occur in the AD brain that warrant renewed emphasis as potential therapeutic targets for this disease. Among those are the elementomic signatures of iron, copper, zinc, and selenium. Here, we review these essential elements of AD for their broad potential to contribute to Alzheimer’s pathophysiology, and we also highlight more recent attempts to translate these findings into therapeutics. A reinspection of large bodies of discovery in the AD field, such as this, may inspire new thinking about pathogenesis and therapeutic targets.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0021-9258
    EISSN: 1083-351X
    DOI: 10.1074/jbc.REV120.008207
    PMID: 33219130
  • Source: DOAJ Directory of Open Access Journals
    PubMed Central
    Alma/SFX Local Collection
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