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Volume electron microscopy: analyzing the lung

Histochemistry and cell biology, 2021-02, Vol.155 (2), p.241-260 [Peer Reviewed Journal]

The Author(s) 2020 ;The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0948-6143 ;EISSN: 1432-119X ;DOI: 10.1007/s00418-020-01916-3 ;PMID: 32944795

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  • Title:
    Volume electron microscopy: analyzing the lung
  • Author: Schneider, Jan Philipp ; Hegermann, Jan ; Wrede, Christoph
  • Subjects: Alveoli ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Developmental Biology ; Electron microscopes ; Epithelium ; Lungs ; Microscopy ; Review ; Scanning electron microscopy ; Sectioning ; Tomography ; Transmission electron microscopy ; Ultrastructure
  • Is Part Of: Histochemistry and cell biology, 2021-02, Vol.155 (2), p.241-260
  • Description: Since its entry into biomedical research in the first half of the twentieth century, electron microscopy has been a valuable tool for lung researchers to explore the lung’s delicate ultrastructure. Among others, it proved the existence of a continuous alveolar epithelium and demonstrated the surfactant lining layer. With the establishment of serial sectioning transmission electron microscopy, as the first “volume electron microscopic” technique, electron microscopy entered the third dimension and investigations of the lung’s three-dimensional ultrastructure became possible. Over the years, further techniques, ranging from electron tomography over serial block-face and focused ion beam scanning electron microscopy to array tomography became available. All techniques cover different volumes and resolutions, and, thus, different scientific questions. This review gives an overview of these techniques and their application in lung research, focusing on their fields of application and practical implementation. Furthermore, an introduction is given how the output raw data are processed and the final three-dimensional models can be generated.
  • Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
  • Language: English
  • Identifier: ISSN: 0948-6143
    EISSN: 1432-119X
    DOI: 10.1007/s00418-020-01916-3
    PMID: 32944795
  • Source: SpringerOpen
    ProQuest Central
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