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Cross-reactive memory T cells and herd immunity to SARS-CoV-2

Nature reviews. Immunology, 2020-11, Vol.20 (11), p.709-713 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;Springer Nature Limited 2020 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-020-00460-4 ;PMID: 33024281

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Title:
Cross-reactive memory T cells and herd immunity to SARS-CoV-2
Author: Lipsitch, Marc ; Grad, Yonatan H ; Sette, Alessandro ; Crotty, Shane
Subjects: Adaptive Immunity - drug effects ; Antibodies, Viral - biosynthesis ; Betacoronavirus - drug effects ; Betacoronavirus - immunology ; Betacoronavirus - pathogenicity ; CD4 antigen ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - virology ; Common cold ; Coronaviridae - drug effects ; Coronaviridae - immunology ; Coronaviridae Infections - epidemiology ; Coronaviridae Infections - immunology ; Coronaviridae Infections - prevention & control ; Coronaviridae Infections - virology ; Coronavirus Infections - epidemiology ; Coronavirus Infections - immunology ; Coronavirus Infections - prevention & control ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; COVID-19 Vaccines ; Cross Reactions ; Disease transmission ; Epidemic models ; Epidemiology ; Health aspects ; Herd immunity ; Humans ; Immunity, Herd - drug effects ; Immunologic Memory ; Immunological memory ; Immunology ; Lymphocytes ; Lymphocytes T ; Memory cells ; Pandemics ; Pandemics - prevention & control ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - immunology ; Pneumonia, Viral - prevention & control ; Pneumonia, Viral - virology ; Rhinovirus - drug effects ; Rhinovirus - immunology ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; T cells ; Viral Vaccines - administration & dosage ; Viral Vaccines - biosynthesis ; Viral Vaccines - immunology
Is Part Of: Nature reviews. Immunology, 2020-11, Vol.20 (11), p.709-713
Description: Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both on COVID-19 disease severity and on viral spread in a population. Here, we reflect on the immunological and epidemiological aspects and implications of pre-existing cross-reactive immune memory to SARS-CoV-2, which largely originates from previous exposure to circulating common cold coronaviruses. We propose four immunological scenarios for the impact of cross-reactive CD4 memory T cells on COVID-19 severity and viral transmission. For each scenario, we discuss its implications for the dynamics of herd immunity and on projections of the global impact of SARS-CoV-2 on the human population, and assess its plausibility. In sum, we argue that key potential impacts of cross-reactive T cell memory are already incorporated into epidemiological models based on data of transmission dynamics, particularly with regard to their implications for herd immunity. The implications of immunological processes on other aspects of SARS-CoV-2 epidemiology are worthy of future study.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/s41577-020-00460-4
PMID: 33024281
Source: MEDLINE
ProQuest Central

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Cross-reactive memory T cells and herd immunity to SARS-CoV-2

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;Springer Nature Limited 2020 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/s41577-020-00460-4 ;PMID: 33024281

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