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Lipid composition of the cancer cell membrane
Journal of bioenergetics and biomembranes, 2020-10, Vol.52 (5), p.321-342
[Peer Reviewed Journal]
The Author(s) 2020 ;Attribution ;ISSN: 0145-479X ;EISSN: 1573-6881 ;DOI: 10.1007/s10863-020-09846-4 ;PMID: 32715369
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Title:
Lipid composition of the cancer cell membrane
Author:
Szlasa, Wojciech
;
Zendran, Iga
;
Zalesińska, Aleksandra
;
Tarek, Mounir
;
Kulbacka, Julita
Subjects:
Animal Anatomy
;
Animal Biochemistry
;
Biochemistry
;
Biochemistry, Molecular Biology
;
Bioorganic Chemistry
;
Biophysics
;
Cancer
;
Chemistry
;
Chemistry and Materials Science
;
Histology
;
Life Sciences
;
Mini-Review
;
Morphology
;
Organic Chemistry
Is Part Of:
Journal of bioenergetics and biomembranes, 2020-10, Vol.52 (5), p.321-342
Description:
Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.
Publisher:
New York: Springer US
Language:
English
Identifier:
ISSN: 0145-479X
EISSN: 1573-6881
DOI: 10.1007/s10863-020-09846-4
PMID: 32715369
Source:
Hyper Article en Ligne (HAL) (Open Access)
Springer Nature OA/Free Journals
ProQuest Central
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