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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report

American journal of respiratory and critical care medicine, 2020-08, Vol.202 (4), p.511-523 [Peer Reviewed Journal]

Copyright American Thoracic Society Aug 15, 2020 ;Copyright © 2020 by the American Thoracic Society 2020 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201908-1595ws ;PMID: 32150460

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Title:
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report
Author: Semler, Matthew W ; Bernard, Gordon R ; Aaron, Shawn D ; Angus, Derek C ; Biros, Michelle H ; Brower, Roy G ; Calfee, Carolyn S ; Colantuoni, Elizabeth A ; Ferguson, Niall D ; Gong, Michelle N ; Hopkins, Ramona O ; Hough, Catherine L ; Iwashyna, Theodore J ; Levy, Bruce D ; Martin, Thomas R ; Matthay, Michael A ; Mizgerd, Joseph P ; Moss, Marc ; Needham, Dale M ; Self, Wesley H ; Seymour, Christopher W ; Stapleton, Renee D ; Thompson, B Taylor ; Wunderink, Richard G ; Aggarwal, Neil R ; Reineck, Lora A
Subjects: Chronic obstructive pulmonary disease ; Clinical trials ; NHLBI Workshop ; Pneumonia ; Precision medicine ; Recovery (Medical) ; Sepsis
Is Part Of: American journal of respiratory and critical care medicine, 2020-08, Vol.202 (4), p.511-523
Description: Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the NHLBI. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have yielded improvements in supportive care, which have translated into improved patient outcomes. Novel therapeutics have largely failed to translate from promising preclinical findings into improved patient outcomes in late-phase clinical trials. Recent advances in personalized medicine, "big data," causal inference using observational data, novel clinical trial designs, preclinical disease modeling, and understanding of recovery from acute illness promise to transform the methods of pulmonary and critical care clinical research. To assess the current state of, research priorities for, and future directions in adult pulmonary and critical care research, the NHLBI assembled a multidisciplinary working group of investigators. This working group identified recommendations for future research, including ) focusing on understanding the clinical, physiological, and biological underpinnings of heterogeneity in syndromes, diseases, and treatment response with the goal of developing targeted, personalized interventions; ) optimizing preclinical models by incorporating comorbidities, cointerventions, and organ support; ) developing and applying novel clinical trial designs; and ) advancing mechanistic understanding of injury and recovery to develop and test interventions targeted at achieving long-term improvements in the lives of patients and families. Specific areas of research are highlighted as especially promising for making advances in pneumonia, acute hypoxemic respiratory failure, and acute respiratory distress syndrome.
Publisher: United States: American Thoracic Society
Language: English
Identifier: ISSN: 1073-449X
EISSN: 1535-4970
DOI: 10.1164/rccm.201908-1595ws
PMID: 32150460
Source: Geneva Foundation Free Medical Journals at publisher websites
Alma/SFX Local Collection

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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report

Copyright American Thoracic Society Aug 15, 2020 ;Copyright © 2020 by the American Thoracic Society 2020 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201908-1595ws ;PMID: 32150460

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