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The Frequency of Ras Mutations in Cancer
Cancer research (Chicago, Ill.), 2020-07, Vol.80 (14), p.2969-2974
[Peer Reviewed Journal]
2020 American Association for Cancer Research. ;ISSN: 0008-5472 ;EISSN: 1538-7445 ;DOI: 10.1158/0008-5472.can-19-3682 ;PMID: 32209560
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Title:
The Frequency of Ras Mutations in Cancer
Author:
Prior, Ian A
;
Hood, Fiona E
;
Hartley, James L
Subjects:
Humans
;
Incidence
;
Mutation
;
Mutation Rate
;
Neoplasms - epidemiology
;
Neoplasms - genetics
;
ras Proteins - genetics
;
Signal Transduction
Is Part Of:
Cancer research (Chicago, Ill.), 2020-07, Vol.80 (14), p.2969-2974
Description:
Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10%-30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of particular cancer types and particular Ras isoforms within these datasets. To provide a more definitive figure for Ras mutation frequency in cancer, we cross-referenced the data in all major publicly accessible cancer mutation databases to determine reliable mutation frequency values for each Ras isoform in all major cancer types. These percentages were then applied to current U.S. cancer incidence statistics to estimate the number of new patients each year that have Ras-mutant cancers. We find that approximately 19% of patients with cancer harbor Ras mutations, equivalent to approximately 3.4 million new cases per year worldwide. We discuss the Ras isoform and mutation-specific trends evident within the datasets that are relevant to current Ras-targeted therapies.
Publisher:
United States
Language:
English
Identifier:
ISSN: 0008-5472
EISSN: 1538-7445
DOI: 10.1158/0008-5472.can-19-3682
PMID: 32209560
Source:
MEDLINE
Alma/SFX Local Collection
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