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SynergyFinder 2.0: visual analytics of multi-drug combination synergies

Nucleic acids research, 2020-07, Vol.48 (W1), p.W488-W493 [Peer Reviewed Journal]

The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. 2020 ;The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. ;info:eu-repo/semantics/openAccess ;ISSN: 0305-1048 ;EISSN: 1362-4962 ;DOI: 10.1093/nar/gkaa216 ;PMID: 32246720

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  • Title:
    SynergyFinder 2.0: visual analytics of multi-drug combination synergies
  • Author: Ianevski, Aleksandr ; Giri, Anil K ; Aittokallio, Tero
  • Subjects: Computer Graphics ; Drug Synergism ; Drug Therapy, Combination ; Software ; Web Server Issue
  • Is Part Of: Nucleic acids research, 2020-07, Vol.48 (W1), p.W488-W493
  • Description: Abstract SynergyFinder (https://synergyfinder.fimm.fi) is a stand-alone web-application for interactive analysis and visualization of drug combination screening data. Since its first release in 2017, SynergyFinder has become a widely used web-tool both for the discovery of novel synergistic drug combinations in pre-clinical model systems (e.g. cell lines or primary patient-derived cells), and for better understanding of mechanisms of combination treatment efficacy or resistance. Here, we describe the latest version of SynergyFinder (release 2.0), which has extensively been upgraded through the addition of novel features supporting especially higher-order combination data analytics and exploratory visualization of multi-drug synergy patterns, along with automated outlier detection procedure, extended curve-fitting functionality and statistical analysis of replicate measurements. A number of additional improvements were also implemented based on the user requests, including new visualization and export options, updated user interface, as well as enhanced stability and performance of the web-tool. With these improvements, SynergyFinder 2.0 is expected to greatly extend its potential applications in various areas of multi-drug combinatorial screening and precision medicine.
  • Publisher: England: Oxford University Press
  • Language: English;Norwegian
  • Identifier: ISSN: 0305-1048
    EISSN: 1362-4962
    DOI: 10.1093/nar/gkaa216
    PMID: 32246720
  • Source: Oxford Journals Open Access Collection
    GFMER Free Medical Journals
    MEDLINE
    NORA Norwegian Open Research Archives
    PubMed Central
    DOAJ Directory of Open Access Journals
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