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The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed

The Journal of nutrition, 2020-06, Vol.150 (6), p.1354-1359 [Peer Reviewed Journal]

2020 American Society for Nutrition. ;Copyright © The Author(s) 2019. 2019 ;Copyright © The Author(s) 2019. ;Copyright American Institute of Nutrition Jun 2020 ;ISSN: 0022-3166 ;EISSN: 1541-6100 ;DOI: 10.1093/jn/nxz308 ;PMID: 31825066

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Title:
The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed
Author: Ludwig, David S
Subjects: Alzheimer disease ; Blood Glucose - metabolism ; Calories ; cancer ; Carbohydrates ; cardiovascular disease ; Clinical medicine ; Clinical trials ; Diabetes ; Diabetes mellitus ; Diet ; Diet, Ketogenic ; Dietary Carbohydrates - administration & dosage ; Glucose ; High fat diet ; Hogs ; Humans ; Insulin ; Insulin - blood ; Insulin Resistance ; Issues and Opinions ; Ketogenesis ; ketogenic diet ; ketones ; Long-term effects ; Low carbohydrate diet ; Low fat diet ; Medicine ; Nutrient deficiency ; Nutrition ; Nutrition Policy ; Obesity ; Obesity - diet therapy ; Obesity - metabolism ; Public health ; vegan diet ; Weight Loss
Is Part Of: The Journal of nutrition, 2020-06, Vol.150 (6), p.1354-1359
Description: For >50 y, dietary guidelines in the United States have focused on reducing intakes of saturated and total fat. However, rates of obesity and diabetes rose markedly throughout this period, with potentially catastrophic implications for public health and the economy. Recently, ketogenic diets have received substantial attention from the general public and nutrition research community. These very-low-carbohydrate diets, with fat comprising >70% of calories, have been dismissed as fads. However, they have a long history in clinical medicine and human evolution. Ketogenic diets appear to be more effective than low-fat diets for treatment of obesity and diabetes. In addition to the reductions in blood glucose and insulin achievable through carbohydrate restriction, chronic ketosis might confer unique metabolic benefits of relevance to cancer, neurodegenerative conditions, and other diseases associated with insulin resistance. Based on available evidence, a well-formulated ketogenic diet does not appear to have major safety concerns for the general public and can be considered a first-line approach for obesity and diabetes. High-quality clinical trials of ketogenic diets will be needed to assess important questions about their long-term effects and full potential in clinical medicine.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0022-3166
EISSN: 1541-6100
DOI: 10.1093/jn/nxz308
PMID: 31825066
Source: MEDLINE
Alma/SFX Local Collection
Oxford Academic Journals (Open Access)

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The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed

2020 American Society for Nutrition. ;Copyright © The Author(s) 2019. 2019 ;Copyright © The Author(s) 2019. ;Copyright American Institute of Nutrition Jun 2020 ;ISSN: 0022-3166 ;EISSN: 1541-6100 ;DOI: 10.1093/jn/nxz308 ;PMID: 31825066

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