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Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants

European heart journal, 2020-03, Vol.41 (11), p.1182-1189 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. 2019 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com. ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehz849 ;PMID: 31848595

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  • Title:
    Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants
  • Author: Fan, Mengyu ; Sun, Dianjianyi ; Zhou, Tao ; Heianza, Yoriko ; Lv, Jun ; Li, Liming ; Qi, Lu
  • Subjects: Biological Specimen Banks ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Clinical Research ; Editor's Choice ; Genetic Predisposition to Disease ; Humans ; Incidence ; Prospective Studies ; Risk Factors ; Sleep ; United Kingdom - epidemiology
  • Is Part Of: European heart journal, 2020-03, Vol.41 (11), p.1182-1189
  • Description: Abstract Aims To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD). Methods and results This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7–8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0–1, participants with a score of 5 had a 35% (19–48%), 34% (22–44%), and 34% (25–42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke. Conclusion In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0195-668X
    EISSN: 1522-9645
    DOI: 10.1093/eurheartj/ehz849
    PMID: 31848595
  • Source: GFMER Free Medical Journals
    MEDLINE
    Alma/SFX Local Collection
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