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Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility: A single-center study

Turkish journal of urology, 2020-03, Vol.46 (2), p.95-100 [Peer Reviewed Journal]

2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://turkishjournalofurology.com/en/copyright-1011 ;Copyright 2020 by Turkish Association of Urology 2020 ;ISSN: 2149-3235 ;EISSN: 2149-3057 ;EISSN: 2980-1478 ;DOI: 10.5152/tud.2019.19156 ;PMID: 32125967

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  • Title:
    Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility: A single-center study
  • Author: Özdemir, Taha Reşid ; Özyılmaz, Berk ; Çakmak, Özgür ; Kaya, Özge Özer ; Köse, Can ; Kırbıyık, Özgür ; Keskin, Mehmet Zeynel ; Koç, Altuğ ; Zeyrek, Tuğba ; Kutbay, Yaşar Bekir ; Erdoğan, Kadri Murat ; Güvenç, Merve Saka
  • Subjects: Andrology ; Infertility ; Urology ; Y chromosomes
  • Is Part Of: Turkish journal of urology, 2020-03, Vol.46 (2), p.95-100
  • Description: The aim of this study was to determine the frequencies of chromosomal abnormalities and Y-chromosome microdeletions in Turkish cases with primary male infertility in a single center. Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively. Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdeletions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%). This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.
  • Publisher: Turkey: Aves Yayincilik Ltd. STI
  • Language: English;Turkish
  • Identifier: ISSN: 2149-3235
    EISSN: 2149-3057
    EISSN: 2980-1478
    DOI: 10.5152/tud.2019.19156
    PMID: 32125967
  • Source: PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
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