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NAD + in Brain Aging and Neurodegenerative Disorders

Cell metabolism, 2019-10, Vol.30 (4), p.630-655 [Peer Reviewed Journal]

Copyright © 2019 Elsevier Inc. All rights reserved. ;info:eu-repo/semantics/openAccess ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2019.09.001 ;PMID: 31577933

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  • Title:
    NAD + in Brain Aging and Neurodegenerative Disorders
  • Author: Lautrup, Sofie ; Sinclair, David A ; Mattson, Mark P ; Fang, Evandro F
  • Is Part Of: Cell metabolism, 2019-10, Vol.30 (4), p.630-655
  • Description: NAD is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD -dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD -based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
  • Publisher: United States: Cell Press
  • Language: English;Norwegian
  • Identifier: ISSN: 1550-4131
    EISSN: 1932-7420
    DOI: 10.1016/j.cmet.2019.09.001
    PMID: 31577933
  • Source: Cell Press Free Archives
    NORA Norwegian Open Research Archives
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