Language:

Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence

Psychopharmacology, 2019-08, Vol.236 (8), p.2307-2323 [Peer Reviewed Journal]

The Author(s) 2019 ;COPYRIGHT 2019 Springer ;Psychopharmacology is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0033-3158 ;EISSN: 1432-2072 ;DOI: 10.1007/s00213-019-05296-y ;PMID: 31218428

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence
Author: Alsiö, Johan ; Phillips, Benjamin U. ; Sala-Bayo, Júlia ; Nilsson, Simon R. O. ; Calafat-Pla, Teresa C. ; Rizwand, Arazo ; Plumbridge, Jessica M. ; López-Cruz, Laura ; Dalley, Jeffrey W. ; Cardinal, Rudolf N. ; Mar, Adam C. ; Robbins, Trevor W.
Subjects: Animals ; Antagonists ; Biomedical and Life Sciences ; Biomedicine ; Cognitive ability ; Computer applications ; Dopamine ; Dopamine - pharmacology ; Dopamine Agonists - pharmacology ; Dopamine Antagonists - pharmacology ; Dopamine D1 receptors ; Dopamine D2 Receptor Antagonists - pharmacology ; Dopamine D2 receptors ; Dopamine receptors ; Feedback ; Feedback, Physiological - drug effects ; Feedback, Physiological - physiology ; Machine learning ; Male ; Mental disorders ; Negative feedback ; Neurosciences ; Original Investigation ; Parameter estimation ; Pharmacology/Toxicology ; Phenols ; Photic Stimulation - methods ; Positive feedback ; Psychiatry ; Quinpirole ; Rats ; Receptors, Dopamine D1 - agonists ; Receptors, Dopamine D1 - antagonists & inhibitors ; Receptors, Dopamine D1 - metabolism ; Receptors, Dopamine D2 - agonists ; Receptors, Dopamine D2 - metabolism ; Reversal learning ; Reversal Learning - drug effects ; Reversal Learning - physiology ; Schizophrenia ; Space Perception - drug effects ; Space Perception - physiology ; Spatial discrimination learning ; Stimulation ; Visual discrimination learning ; Visual Perception - drug effects ; Visual Perception - physiology ; Visual tasks
Is Part Of: Psychopharmacology, 2019-08, Vol.236 (8), p.2307-2323
Description: Rationale Dopamine D2-like receptors (D2R) are important drug targets in schizophrenia and Parkinson’s disease, but D2R ligands also cause cognitive inflexibility such as poor reversal learning. The specific role of D2R in reversal learning remains unclear. Objectives We tested the hypotheses that D2R agonism impairs reversal learning by blocking negative feedback and that antagonism of D1-like receptors (D1R) impairs learning from positive feedback. Methods Male Lister Hooded rats were trained on a novel visual reversal learning task. Performance on “probe trials”, during which the correct or incorrect stimulus was presented with a third, probabilistically rewarded (50% of trials) and therefore intermediate stimulus, revealed individual learning curves for the processes of positive and negative feedback. The effects of D2R and D1R agonists and antagonists were evaluated. A separate cohort was tested on a spatial probabilistic reversal learning (PRL) task after D2R agonism. Computational reinforcement learning modelling was applied to choice data from the PRL task to evaluate the contribution of latent factors. Results D2R agonism with quinpirole dose-dependently impaired both visual reversal and PRL. Analysis of the probe trials on the visual task revealed a complete blockade of learning from negative feedback at the 0.25 mg/kg dose, while learning from positive feedback was intact. Estimated parameters from the model that best described the PRL choice data revealed a steep and selective decrease in learning rate from losses. D1R antagonism had a transient effect on the positive probe trials. Conclusions D2R stimulation impairs reversal learning by blocking the impact of negative feedback.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0033-3158
EISSN: 1432-2072
DOI: 10.1007/s00213-019-05296-y
PMID: 31218428
Source: ProQuest One Psychology
MEDLINE
Springer Nature OA/Free Journals
ProQuest Central

Back to results list

Previous Result 2 Next Go to Next page


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence

Searching Remote Databases, Please Wait