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Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study

Neurology, 2019-07, Vol.93 (5), p.e445-e457 [Peer Reviewed Journal]

2019 American Academy of Neurology ;2019 American Academy of Neurology. ;2019 American Academy of Neurology 2019 American Academy of Neurology ;ISSN: 0028-3878 ;EISSN: 1526-632X ;DOI: 10.1212/WNL.0000000000007853 ;PMID: 31266905

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  • Title:
    Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study
  • Author: Ma, Chaoran ; Gurol, M Edip ; Huang, Zhe ; Lichtenstein, Alice H ; Wang, Xiuyan ; Wang, Yuzhen ; Neumann, Samantha ; Wu, Shouling ; Gao, Xiang
  • Subjects: Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - epidemiology ; China - epidemiology ; Cholesterol, LDL - blood ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
  • Is Part Of: Neurology, 2019-07, Vol.93 (5), p.e445-e457
  • Description: OBJECTIVETo prospectively examine the association between low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations and intracerebral hemorrhage (ICH) risk. METHODSThe current cohort study included 96,043 participants (mean age 51.3 years) who were free of stroke, myocardial infarction, and cancer at baseline (2006). Serum LDL-C concentrations were assessed in 2006, 2008, 2010, and 2012. Cumulative average LDL-C concentrations were calculated from all available LDL-C data during that period. Incident ICH was confirmed by review of medical records. RESULTSWe identified 753 incident ICH cases during 9 years of follow-up. The ICH risk was similar among participants with LDL concentrations of 70 to 99 mg/dL and those with LDL-C concentrations ≥100 mg/dL. In contrast, participants with LDL-C concentrations <70 mg/dL had a significantly higher risk of developing ICH than those with LDL-C concentrations of 70 to 99 mg/dL; adjusted hazard ratios were 1.65 (95% confidence interval [CI] 1.32–2.05) for LDL-C concentrations of 50 to 69 mg/dL and 2.69 (95% CI 2.03–3.57) for LDL-C concentrations <50 mg/dL. CONCLUSIONSWe observed a significant association between lower LDL-C and higher risk of ICH when LDL-C was <70 mg/dL, and the association became nonsignificant when LDL-C ≥70 mg/dL. These data can help determination of the ideal LDL range in patients who are at increased risk of both atherosclerotic disease and hemorrhagic stroke and guide planning of future lipid-lowering studies.
  • Publisher: United States: American Academy of Neurology
  • Language: English
  • Identifier: ISSN: 0028-3878
    EISSN: 1526-632X
    DOI: 10.1212/WNL.0000000000007853
    PMID: 31266905
  • Source: MEDLINE
    Alma/SFX Local Collection
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