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Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

Cell, 2019-04, Vol.177 (3), p.541-555.e17 [Peer Reviewed Journal]

2019 ;Published by Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2019.02.028 ;PMID: 30955887

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Title:
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage
Author: Uderhardt, Stefan ; Martins, Andrew J. ; Tsang, John S. ; Lämmermann, Tim ; Germain, Ronald N.
Subjects: Alarmins - metabolism ; Animals ; anti-inflammation ; cloaking ; collateral damage ; damage response ; Endocytosis ; Inflammation - immunology ; Inflammation - metabolism ; Inflammation - pathology ; inflammation prevention ; intravital imaging ; Macrophages - immunology ; Macrophages - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Fluorescence ; Muscle Fibers, Skeletal - pathology ; Neutrophil Activation ; neutrophil swarming ; Neutrophils - immunology ; Neutrophils - metabolism ; resident macrophages ; Sialic Acid Binding Ig-like Lectin 1 - metabolism ; tissue homeostasis ; tissue protection
Is Part Of: Cell, 2019-04, Vol.177 (3), p.541-555.e17
Description: Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an inescapable consequence of parenchymal cell death has not been explored. Using a combination of dynamic intravital imaging and confocal multiplex microscopy, we report here that tissue-resident macrophages rapidly sense the death of individual cells and extend membrane processes that sequester the damage, a process that prevents initiation of the feedforward chemoattractant signaling cascade that results in neutrophil swarms. Through this “cloaking” mechanism, the resident macrophages prevent neutrophil-mediated inflammatory damage, maintaining tissue homeostasis in the face of local cell injury that occurs on a regular basis in many organs because of mechanical and other stresses. [Display omitted] [Display omitted] •Resident tissue macrophages (RTMs) respond to tissue damage and cloak the debris•Cloaking by RTM prevents neutrophil activation and neutrophil-driven inflammation•Cloaking by RTM prevents excess tissue damage and preserves tissue homeostasis In order to maintain homeostasis, tissue-resident macrophages surround and hide very small tissue lesions to prevent excess inflammation driven by neutrophils.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2019.02.028
PMID: 30955887
Source: MEDLINE
Open Access: Cell Press Free Archives

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Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

2019 ;Published by Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2019.02.028 ;PMID: 30955887

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