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Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC)

Diabetes (New York, N.Y.), 2019-02, Vol.68 (2), p.409-419 [Peer Reviewed Journal]

2018 by the American Diabetes Association. ;Copyright American Diabetes Association Feb 1, 2019 ;2018 by the American Diabetes Association. 2018 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db18-0515 ;PMID: 30409781

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Title:
Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC)
Author: Miller, Rachel G ; Costacou, Tina ; Orchard, Trevor J
Subjects: Adolescent ; Age ; Angina ; Arteriosclerosis ; Blood Glucose - metabolism ; Blood pressure ; Blood Pressure - physiology ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - metabolism ; Cerebral infarction ; Child ; Children ; Cholesterol ; Complications ; Diabetes ; Diabetes Complications - epidemiology ; Diabetes Complications - metabolism ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - etiology ; Diabetes Mellitus, Type 1 - metabolism ; EKG ; Epidemiology ; Excretion ; Female ; Glycated Hemoglobin A - metabolism ; Health risk assessment ; Humans ; Hypertension ; Ischemia ; Kidney diseases ; Low density lipoprotein ; Male ; Myocardial infarction ; Prospective Studies ; Risk Factors ; Smoking ; Triglycerides
Is Part Of: Diabetes (New York, N.Y.), 2019-02, Vol.68 (2), p.409-419
Description: In a recent Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study report, mean HbA was the strongest predictor of cardiovascular disease (CVD) after age. In DCCT/EDIC, mean diabetes duration was 6 years (median 4) at baseline and those with high blood pressure or cholesterol were excluded. We now replicate these analyses in the Pittsburgh Epidemiology of Diabetes Complications (EDC) prospective cohort study of childhood-onset (at <17 years of age) type 1 diabetes, with similar age (mean 27 years in both studies) but longer diabetes duration (mean 19 years and median 18 years) and no CVD risk factor exclusion at baseline. CVD incidence (CVD death, myocardial infarction (MI), stroke, revascularization, angina, or ischemic electrocardiogram) was associated with diabetes duration, most recent albumin excretion rate (AER), updated mean triglycerides, baseline hypertension, baseline LDL cholesterol, and most recent HbA Major atherosclerotic cardiovascular events (CVD death, MI, or stroke) were associated with diabetes duration, most recent AER, baseline systolic blood pressure, baseline smoking, and updated mean HbA Compared with findings in DCCT/EDIC, traditional risk factors similarly predicted CVD; however AER predominates in EDC and HbA in DCCT/EDIC. Thus, the relative impact of HbA and kidney disease in type 1 diabetes varies according to diabetes duration.
Publisher: United States: American Diabetes Association
Language: English
Identifier: ISSN: 0012-1797
EISSN: 1939-327X
DOI: 10.2337/db18-0515
PMID: 30409781
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection

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Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC)

2018 by the American Diabetes Association. ;Copyright American Diabetes Association Feb 1, 2019 ;2018 by the American Diabetes Association. 2018 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db18-0515 ;PMID: 30409781

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