Language:

n–3 Fatty Acid Supplementation in Mothers, Preterm Infants, and Term Infants and Childhood Psychomotor and Visual Development: A Systematic Review and Meta-Analysis

The Journal of nutrition, 2018-03, Vol.148 (3), p.409-418 [Peer Reviewed Journal]

2018 American Society for Nutrition. ;Copyright American Institute of Nutrition Mar 2018 ;2018 American Society for Nutrition. All rights reserved 2018 ;ISSN: 0022-3166 ;EISSN: 1541-6100 ;DOI: 10.1093/jn/nxx031 ;PMID: 29546296

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
n–3 Fatty Acid Supplementation in Mothers, Preterm Infants, and Term Infants and Childhood Psychomotor and Visual Development: A Systematic Review and Meta-Analysis
Author: Shulkin, Masha ; Pimpin, Laura ; Bellinger, David ; Kranz, Sarah ; Fawzi, Wafaie ; Duggan, Christopher ; Mozaffarian, Dariush
Subjects: Acuity ; Adolescent ; Adult ; Age ; Bayley Scales of Infant Development ; Child ; Child development ; Child Development - drug effects ; childhood ; Children ; cognition ; Cognition & reasoning ; Cognition - drug effects ; Cognitive ability ; development ; Dietary Supplements ; Epidemiology ; Evidence-based medicine ; Fatty acids ; Fatty Acids, Omega-3 - pharmacology ; Female ; Gestational Age ; Humans ; Infant ; infant formula ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Infant, Premature ; Infants ; Intelligence ; Intervention ; long-chain n–3 polyunsaturated fatty acids ; Male ; Maternal Nutritional Physiological Phenomena ; Meta-analysis ; Mothers ; Nutrition ; Nutritional Epidemiology ; Polyunsaturated fatty acids ; Premature babies ; prenatal ; Psychomotor Performance - drug effects ; Regression analysis ; Seafood ; Statistical analysis ; Subgroups ; Supplementation ; supplementation trials ; Systematic review ; Visual acuity ; Visual Acuity - drug effects ; Visual effects ; Young Adult
Is Part Of: The Journal of nutrition, 2018-03, Vol.148 (3), p.409-418
Description: Epidemiologic studies link maternal seafood and n–3 (ω-3) polyunsaturated fatty acid (PUFA) consumption with improved childhood cognitive development; trials show mixed results. We investigated effects of n–3 PUFA supplementation on child cognitive and visual outcomes. We systematically reviewed and meta-analyzed randomized controlled trials of n–3 PUFA supplementation in mothers or infants (age ≤2 y) and evaluated standardized measures of cognitive or visual development up to age 18 y. Of 6286 abstracts and 669 full-text articles, 38 trials with 53 intervention arms were included. Data were extracted independently in duplicate. Findings were pooled using random-effects meta-analysis across supplementation periods (maternal, preterm, term infant); we also explored subgroup analyses stratified by supplementation period. Heterogeneity was explored using I2, stratified analysis, and meta-regression. Cognitive development was assessed by Bayley Scales of Infant Development mental and psychomotor developmental indexes (MDI, PDI) and intelligence quotient (IQ); visual acuity was assessed by electrophysiological or behavioral measures. The 38 trials (mothers: n = 13; preterm infants: n = 7; term infants: n = 18) included 5541 participants. When we explored effects during different periods of supplementation, n–3 PUFA supplementation improved MDI in preterm infants (3.33; 95% CI: 0.72, 5.93), without statistically significant effects on PDI or IQ in different intervention period subgroups. Visual acuity [measured as the logarithm of the minimum angle of resolution (logMAR)] was improved by supplementation in preterm (–0.08 logMAR; 95% CI: –0.14, –0.01 logMAR) and term infants (–0.08 logMAR; 95% CI: –0.11, –0.05 logMAR), with a nonsignificant trend for maternal supplementation (–0.02 logMAR; 95% CI: –0.04, 0.00 logMAR). In main analyses pooling all supplementation periods, compared with placebo, n–3 PUFA supplementation improved MDI (n = 21 trials; 0.91; 95% CI: 0.005, 1.81; P = 0.049), PDI (n = 21 trials; 1.06 higher index; 95% CI: 0.10, 2.03; P = 0.031), and visual acuity (n = 24; –0.063 logMAR; 95% CI: –0.084, –0.041 logMAR; P < 0.001) but not IQ (n = 7; 0.20; 95% CI: –1.56, 1.96, P = 0.83), although few studies assessed this endpoint. Potential publication bias was identified for MDI (Eggers P = 0.005), but not other endpoints. Significant differences in findings were not identified by world region, race, maternal education, age at outcome assessment, supplementation duration, DHA or EPA dose, DHA:AA ratio, or study quality score (P-interaction > 0.05 each). n–3 PUFA supplementation improves childhood psychomotor and visual development, without significant effects on global IQ later in childhood, although the latter conclusion is based on fewer studies.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0022-3166
EISSN: 1541-6100
DOI: 10.1093/jn/nxx031
PMID: 29546296
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

n–3 Fatty Acid Supplementation in Mothers, Preterm Infants, and Term Infants and Childhood Psychomotor and Visual Development: A Systematic Review and Meta-Analysis

2018 American Society for Nutrition. ;Copyright American Institute of Nutrition Mar 2018 ;2018 American Society for Nutrition. All rights reserved 2018 ;ISSN: 0022-3166 ;EISSN: 1541-6100 ;DOI: 10.1093/jn/nxx031 ;PMID: 29546296

Searching Remote Databases, Please Wait