Language:

Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance

International Journal of Obesity, 2018-03, Vol.42 (3), p.391-397 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Mar 2018 ;Copyright © 2018 The Author(s) 2018 The Author(s) ;ISSN: 0307-0565 ;EISSN: 1476-5497 ;DOI: 10.1038/ijo.2017.231 ;PMID: 28990588

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance
Author: Banks, W A ; Farr, S A ; Salameh, T S ; Niehoff, M L ; Rhea, E M ; Morley, J E ; Hanson, A J ; Hansen, K M ; Craft, S
Subjects: Aged ; Animals ; Antigens, CD - metabolism ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Care and treatment ; Cerebrospinal fluid ; Cognition ; Cognition - drug effects ; Cognitive ability ; Development and progression ; Dyslipidemia ; Dyslipidemias ; Feeding ; Female ; Gemfibrozil ; Gemfibrozil - pharmacology ; Health aspects ; Human behavior ; Humans ; Hypertriglyceridemia ; Hypothalamus ; In vivo methods and tests ; Insulin ; Insulin resistance ; Insulin Resistance - physiology ; Learning ; Leptin ; Leptin - metabolism ; Leptin - pharmacology ; Lipids ; Male ; Maze Learning - drug effects ; Memory ; Metabolic disorders ; Original ; Physiological aspects ; Receptor mechanisms ; Receptor, Insulin - metabolism ; Receptors ; Satiety ; Satiety Response - drug effects ; Triglycerides ; Triglycerides - blood ; Triglycerides - cerebrospinal fluid ; Triglycerides - metabolism ; Triolein ; Triolein - metabolism ; Triolein - pharmacology ; Western blotting
Is Part Of: International Journal of Obesity, 2018-03, Vol.42 (3), p.391-397
Description: Resistance at the brain receptors for leptin and insulin has been associated with increased feeding, obesity and cognitive impairments. The causal agent for central resistance is unknown but could be derived from the blood. Here we postulate whether hypertriglyceridemia, the major dyslipidemia of the metabolic syndrome, could underlie central leptin and insulin resistance. We used radioactively labeled triglycerides to measure blood-brain barrier (BBB) penetration, western blots to measure receptor activation, and feeding and cognitive tests to assess behavioral endpoints. Human CSF was determined to contain triglycerides, a finding previously unclear. The radioactive triglyceride triolein readily crossed the BBB and centrally administered triolein and peripherally administered lipids induced in vivo leptin and/or insulin resistance at hypothalamic receptors. Central triolein blocked the satiety effect of centrally administered leptin. Decreasing serum triglycerides with gemfibrozil improved both learning and memory inversely proportionate to triglyceride levels. Triglycerides cross the blood-brain barrier rapidly, are found in human cerebrospinal fluid, and induce central leptin and insulin receptor resistance, decreasing satiety and cognition.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0307-0565
EISSN: 1476-5497
DOI: 10.1038/ijo.2017.231
PMID: 28990588
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Mar 2018 ;Copyright © 2018 The Author(s) 2018 The Author(s) ;ISSN: 0307-0565 ;EISSN: 1476-5497 ;DOI: 10.1038/ijo.2017.231 ;PMID: 28990588

Searching Remote Databases, Please Wait