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Genetic polymorphisms of IL-6 promoter in cancer susceptibility and prognosis: a meta-analysis
Oncotarget, 2018-02, Vol.9 (15), p.12351-12364
Copyright: © 2018 Peng et al. 2018 ;ISSN: 1949-2553 ;EISSN: 1949-2553 ;DOI: 10.18632/oncotarget.24033 ;PMID: 29552316
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Title:
Genetic polymorphisms of IL-6 promoter in cancer susceptibility and prognosis: a meta-analysis
Author:
Peng, Xingchun
;
Shi, Jun
;
Sun, Wanqun
;
Ruan, Xuzhi
;
Guo, Yang
;
Zhao, Lunhua
;
Wang, Jue
;
Li, Bin
Subjects:
Meta-Analysis
Is Part Of:
Oncotarget, 2018-02, Vol.9 (15), p.12351-12364
Description:
IL-6 is critical for tumorigenesis. However, previous studies on the association of IL-6 promoter polymorphisms with predisposition to different cancer types are somewhat contradictory. Therefore, we performed this meta-analysis regarding the relationship between IL-6 promoter single nucleotide polymorphisms and cancer susceptibility and prognosis. Up to April 2017, 97 original publications were identified covering three IL-6 promoter SNPs. Our results showed statistically significant association between IL-6 promoter and cancer risk and prognosis. Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer. Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia. Furthermore, IL-6 promoter polymorphisms were significantly associated with the prognosis of cancer. Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.
Publisher:
United States: Impact Journals LLC
Language:
English
Identifier:
ISSN: 1949-2553
EISSN: 1949-2553
DOI: 10.18632/oncotarget.24033
PMID: 29552316
Source:
GFMER Free Medical Journals
PubMed Central
Alma/SFX Local Collection
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