Language:

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Cell metabolism, 2018-03, Vol.27 (3), p.513-528 [Peer Reviewed Journal]

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2017.11.002 ;PMID: 29249689

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Author: Yoshino, Jun ; Baur, Joseph A. ; Imai, Shin-ichiro
Subjects: aging ; Aging - metabolism ; Animals ; Humans ; metabolism ; NAD ; NAD - metabolism ; NAMPT ; Niacinamide - analogs & derivatives ; Niacinamide - metabolism ; nicotinamide adenine dinucleotide ; nicotinamide mononucleotide ; Nicotinamide Mononucleotide - metabolism ; nicotinamide phosphoribosyltransferase ; nicotinamide riboside ; NMN ; NMN adenylyltransferases ; NMNATs ; NR kinases ; NRKs ; PARPs ; poly-ADP-ribose polymerases ; Pyridinium Compounds ; sirtuins
Is Part Of: Cell metabolism, 2018-03, Vol.27 (3), p.513-528
Description: Research on the biology of NAD+ has been gaining momentum, providing many critical insights into the pathogenesis of age-associated functional decline and diseases. In particular, two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been extensively studied over the past several years. Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions. Although the pharmacokinetics and metabolic fates of NMN and NR are still under intensive investigation, these NAD+ intermediates can exhibit distinct behavior, and their fates appear to depend on the tissue distribution and expression levels of NAD+ biosynthetic enzymes, nucleotidases, and presumptive transporters for each. A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health. NAD+ is increasingly being recognized to play an important role in the pathogenesis of age-associated functional decline and diseases. Two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been instrumental in driving recent discoveries. We discuss key findings and future therapeutic and translational potential for these molecules.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1550-4131
EISSN: 1932-7420
DOI: 10.1016/j.cmet.2017.11.002
PMID: 29249689
Source: MEDLINE
Open Access: Cell Press Free Archives

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;ISSN: 1550-4131 ;EISSN: 1932-7420 ;DOI: 10.1016/j.cmet.2017.11.002 ;PMID: 29249689

Searching Remote Databases, Please Wait