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dTBC1D7 regulates systemic growth independently of TSC through insulin signaling

The Journal of cell biology, 2018-02, Vol.217 (2), p.517-526 [Peer Reviewed Journal]

2018 Ren et al. ;Copyright Rockefeller University Press Feb 2018 ;2018 Ren et al. 2018 ;ISSN: 0021-9525 ;EISSN: 1540-8140 ;DOI: 10.1083/jcb.201706027 ;PMID: 29187524

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Title:
dTBC1D7 regulates systemic growth independently of TSC through insulin signaling
Author: Ren, Suxia ; Huang, Zengyi ; Jiang, Yuqiang ; Wang, Tao
Subjects: Animals ; Biosynthesis ; Brain ; Carrier Proteins - metabolism ; Cells, Cultured ; Drosophila ; Drosophila Proteins - metabolism ; Fruit flies ; Gene expression ; Insects ; Insulin ; Insulin - metabolism ; Male ; Mutants ; Mutation ; Oxidative stress ; Physiology ; Signal Transduction ; Signaling ; Tuberous sclerosis ; Tuberous Sclerosis - metabolism
Is Part Of: The Journal of cell biology, 2018-02, Vol.217 (2), p.517-526
Description: The insulin signaling pathway plays key roles in systemic growth. TBC1D7 has recently been identified as the third subunit of the tuberous sclerosis complex (TSC), a negative regulator of cell growth. Here, we used as a model system to dissect the physiological function of TBC1D7 in vivo. In mutants lacking TBC1D7, cell and organ growth were promoted, and TBC1D7 limited cell growth in a cell-nonautonomous and TSC-independent manner. TBC1D7 is specifically expressed in insulin-producing cells in the fly brain and regulated biosynthesis and release of insulin-like peptide 2, leading to systemic growth. Furthermore, animals carrying the mutation were hypoglycemic, short-lived, and sensitive to oxidative stress. Our findings provide new insights into the physiological function of TBC1D7 in the systemic control of growth, as well as insights into human disorders caused by mutation.
Publisher: United States: Rockefeller University Press
Language: English
Identifier: ISSN: 0021-9525
EISSN: 1540-8140
DOI: 10.1083/jcb.201706027
PMID: 29187524
Source: Geneva Foundation Free Medical Journals at publisher websites
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PubMed Central

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dTBC1D7 regulates systemic growth independently of TSC through insulin signaling

2018 Ren et al. ;Copyright Rockefeller University Press Feb 2018 ;2018 Ren et al. 2018 ;ISSN: 0021-9525 ;EISSN: 1540-8140 ;DOI: 10.1083/jcb.201706027 ;PMID: 29187524

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