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The Hierarchical Cortical Organization of Human Speech Processing

The Journal of neuroscience, 2017-07, Vol.37 (27), p.6539-6557 [Peer Reviewed Journal]

Copyright © 2017 the authors 0270-6474/17/376539-19$15.00/0. ;Copyright © 2017 the authors 0270-6474/17/376539-19$15.00/0 2017 ;ISSN: 0270-6474 ;EISSN: 1529-2401 ;DOI: 10.1523/jneurosci.3267-16.2017 ;PMID: 28588065

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  • Title:
    The Hierarchical Cortical Organization of Human Speech Processing
  • Author: de Heer, Wendy A ; Huth, Alexander G ; Griffiths, Thomas L ; Gallant, Jack L ; Theunissen, Frédéric E
  • Subjects: Adult ; Brain ; Brain mapping ; Cerebral Cortex - physiology ; Cochlea ; Computer Simulation ; Cortex ; Feature extraction ; Female ; Functional magnetic resonance imaging ; Hemispheres ; Humans ; Male ; Models, Neurological ; Nerve Net - physiology ; Neural Pathways - physiology ; Representations ; Semantics ; Spectra ; Speech ; Speech perception ; Speech Perception - physiology ; Speech processing ; Temporal lobe ; Variance analysis
  • Is Part Of: The Journal of neuroscience, 2017-07, Vol.37 (27), p.6539-6557
  • Description: Speech comprehension requires that the brain extract semantic meaning from the spectral features represented at the cochlea. To investigate this process, we performed an fMRI experiment in which five men and two women passively listened to several hours of natural narrative speech. We then used voxelwise modeling to predict BOLD responses based on three different feature spaces that represent the spectral, articulatory, and semantic properties of speech. The amount of variance explained by each feature space was then assessed using a separate validation dataset. Because some responses might be explained equally well by more than one feature space, we used a variance partitioning analysis to determine the fraction of the variance that was uniquely explained by each feature space. Consistent with previous studies, we found that speech comprehension involves hierarchical representations starting in primary auditory areas and moving laterally on the temporal lobe: spectral features are found in the core of A1, mixtures of spectral and articulatory in STG, mixtures of articulatory and semantic in STS, and semantic in STS and beyond. Our data also show that both hemispheres are equally and actively involved in speech perception and interpretation. Further, responses as early in the auditory hierarchy as in STS are more correlated with semantic than spectral representations. These results illustrate the importance of using natural speech in neurolinguistic research. Our methodology also provides an efficient way to simultaneously test multiple specific hypotheses about the representations of speech without using block designs and segmented or synthetic speech. To investigate the processing steps performed by the human brain to transform natural speech sound into meaningful language, we used models based on a hierarchical set of speech features to predict BOLD responses of individual voxels recorded in an fMRI experiment while subjects listened to natural speech. Both cerebral hemispheres were actively involved in speech processing in large and equal amounts. Also, the transformation from spectral features to semantic elements occurs early in the cortical speech-processing stream. Our experimental and analytical approaches are important alternatives and complements to standard approaches that use segmented speech and block designs, which report more laterality in speech processing and associated semantic processing to higher levels of cortex than reported here.
  • Publisher: United States: Society for Neuroscience
  • Language: English
  • Identifier: ISSN: 0270-6474
    EISSN: 1529-2401
    DOI: 10.1523/jneurosci.3267-16.2017
    PMID: 28588065
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    Alma/SFX Local Collection
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