Language:

Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study

Oncotarget, 2017-06, Vol.8 (24), p.39296-39308

Copyright: © 2017 Yamada et al. 2017 ;ISSN: 1949-2553 ;EISSN: 1949-2553 ;DOI: 10.18632/oncotarget.16945 ;PMID: 28445147

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study
Author: Yamada, Yoshiji ; Sakuma, Jun ; Takeuchi, Ichiro ; Yasukochi, Yoshiki ; Kato, Kimihiko ; Oguri, Mitsutoshi ; Fujimaki, Tetsuo ; Horibe, Hideki ; Muramatsu, Masaaki ; Sawabe, Motoji ; Fujiwara, Yoshinori ; Taniguchi, Yu ; Obuchi, Shuichi ; Kawai, Hisashi ; Shinkai, Shoji ; Mori, Seijiro ; Arai, Tomio ; Tanaka, Masashi
Subjects: Asian Continental Ancestry Group - genetics ; Body Mass Index ; Case-Control Studies ; Chromosomes, Human, Pair 11 ; Exome ; Female ; Follow-Up Studies ; Genetic Markers ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Metabolic Syndrome - genetics ; Middle Aged ; Obesity - genetics ; Polymorphism, Single Nucleotide ; Prognosis ; Research Paper
Is Part Of: Oncotarget, 2017-06, Vol.8 (24), p.39296-39308
Description: We have performed exome-wide association studies to identify genetic variants that influence body mass index or confer susceptibility to obesity or metabolic syndrome in Japanese. The exome-wide association study for body mass index included 12,890 subjects, and those for obesity and metabolic syndrome included 12,968 subjects (3954 individuals with obesity, 9014 controls) and 6817 subjects (3998 individuals with MetS, 2819 controls), respectively. Exome-wide association studies were performed with Illumina HumanExome-12 DNA Analysis BeadChip or Infinium Exome-24 BeadChip arrays. The relation of genotypes of single nucleotide polymorphisms to body mass index was examined by linear regression analysis, and that of allele frequencies of single nucleotide polymorphisms to obesity or metabolic syndrome was evaluated with Fisher's exact test. The exome-wide association studies identified six, 11, and 40 single nucleotide polymorphisms as being significantly associated with body mass index, obesity (P <1.21 × 10-6), or metabolic syndrome (P <1.20 × 10-6), respectively. Subsequent multivariable logistic regression analysis with adjustment for age and sex revealed that three and five single nucleotide polymorphisms were related (P < 0.05) to obesity or metabolic syndrome, respectively, with one of these latter polymorphisms-rs7350481 (C/T) at chromosome 11q23.3-also being significantly (P < 3.13 × 10-4) associated with metabolic syndrome. The polymorphism rs7350481 may thus be a novel susceptibility locus for metabolic syndrome in Japanese. In addition, single nucleotide polymorphisms in three genes (CROT, TSC1, RIN3) and at four loci (ANKK1, ZNF804B, CSRNP3, 17p11.2) were implicated as candidate determinants of obesity and metabolic syndrome, respectively.
Publisher: United States: Impact Journals LLC
Language: English
Identifier: ISSN: 1949-2553
EISSN: 1949-2553
DOI: 10.18632/oncotarget.16945
PMID: 28445147
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Identification of rs7350481 at chromosome 11q23.3 as a novel susceptibility locus for metabolic syndrome in Japanese individuals by an exome-wide association study

Copyright: © 2017 Yamada et al. 2017 ;ISSN: 1949-2553 ;EISSN: 1949-2553 ;DOI: 10.18632/oncotarget.16945 ;PMID: 28445147

Searching Remote Databases, Please Wait