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Application of Fluorescence In Situ Hybridization (FISH) Technique for the Detection of Genetic Aberration in Medical Science

Curēus (Palo Alto, CA), 2017-06, Vol.9 (6), p.e1325-e1325 [Peer Reviewed Journal]

Copyright © 2017, Ratan et al. This work is licensed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright © 2017, Ratan et al. 2017 Ratan et al. ;ISSN: 2168-8184 ;EISSN: 2168-8184 ;DOI: 10.7759/cureus.1325 ;PMID: 28690958

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  • Title:
    Application of Fluorescence In Situ Hybridization (FISH) Technique for the Detection of Genetic Aberration in Medical Science
  • Author: Ratan, Zubair Ahmed ; Zaman, Sojib Bin ; Mehta, Varshil ; Haidere, Mohammad Faisal ; Runa, Nusrat Jahan ; Akter, Nasrin
  • Subjects: Genetics ; Internal Medicine ; Public Health
  • Is Part Of: Curēus (Palo Alto, CA), 2017-06, Vol.9 (6), p.e1325-e1325
  • Description: Fluorescence in situ hybridization (FISH) is a macromolecule recognition technique, which is considered as a new advent in the field of cytology. Initially, it was developed as a physical mapping tool to delineate genes within chromosomes. The accuracy and versatility of FISH were subsequently capitalized upon in biological and medical research. This visually appealing technique provides an intermediate degree of resolution between DNA analysis and chromosomal investigations. FISH consists of a hybridizing DNA probe, which can be labeled directly or indirectly. In the case of direct labeling, fluorescent nucleotides are used, while indirect labeling is incorporated with reporter molecules that are subsequently detected by fluorescent antibodies or other affinity molecules. FISH is applied to detect genetic abnormalities that include different characteristic gene fusions or the presence of an abnormal number of chromosomes in a cell or loss of a chromosomal region or a whole chromosome. It is also applied in different research applications, such as gene mapping or the identification of novel oncogenes. This article reviews the concept of FISH, its application, and its advantages in medical science.
  • Publisher: United States: Cureus Inc
  • Language: English
  • Identifier: ISSN: 2168-8184
    EISSN: 2168-8184
    DOI: 10.7759/cureus.1325
    PMID: 28690958
  • Source: PubMed Central
    ProQuest Central
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