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Abnormal wiring of CCK + basket cells disrupts spatial information coding

Nature neuroscience, 2017-06, Vol.20 (6), p.784-792 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2017 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/nn.4544 ;PMID: 28394324

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Title:
Abnormal wiring of CCK + basket cells disrupts spatial information coding
Author: Del Pino, Isabel ; Brotons-Mas, Jorge R ; Marques-Smith, André ; Marighetto, Aline ; Frick, Andreas ; Marín, Oscar ; Rico, Beatriz
Subjects: Amino Acid Transport Systems, Acidic - metabolism ; Animals ; CA1 Region, Hippocampal - metabolism ; CA1 Region, Hippocampal - physiology ; Cerebral Cortex - metabolism ; Cerebral Cortex - physiology ; Cholecystokinin ; Cholecystokinin - genetics ; Cholecystokinin - metabolism ; Cholecystokinin - physiology ; Circuits ; Coding ; Cortex ; Disruption ; ErbB-2 protein ; Exploratory behavior ; Exploratory Behavior - physiology ; GABAergic Neurons - metabolism ; GABAergic Neurons - physiology ; Glutamic acid transporter ; Integration ; Interneurons ; Interneurons - metabolism ; Interneurons - physiology ; Locomotion - physiology ; Male ; Maze Learning - physiology ; Mice ; Mice, Transgenic ; Neural Inhibition - physiology ; Neural networks ; Neural Pathways - physiology ; Place Cells - physiology ; Prepulse Inhibition - physiology ; Protein-tyrosine kinase ; Protein-tyrosine kinase receptors ; Pyramidal cells ; Pyramidal Cells - physiology ; Receptor, ErbB-4 - biosynthesis ; Receptor, ErbB-4 - genetics ; Receptor, ErbB-4 - physiology ; Rodents ; Spatial analysis (Statistics) ; Spatial discrimination learning ; Spatial Learning - physiology ; Spatial memory ; Spatial Memory - physiology ; Synapses ; Theta Rhythm - physiology ; Theta rhythms ; Tyrosine ; Wiring
Is Part Of: Nature neuroscience, 2017-06, Vol.20 (6), p.784-792
Description: The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3). The number of inhibitory synapses made by CCK VGlut3 basket cells and the inhibitory drive they exerted on pyramidal cells were reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminished the power of theta oscillations during exploratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK basket cells in cortical networks is key to support spatial coding in the hippocampus.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1097-6256
EISSN: 1546-1726
DOI: 10.1038/nn.4544
PMID: 28394324
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Abnormal wiring of CCK + basket cells disrupts spatial information coding

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Jun 2017 ;ISSN: 1097-6256 ;EISSN: 1546-1726 ;DOI: 10.1038/nn.4544 ;PMID: 28394324

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