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K13 Propeller Mutations in Plasmodium falciparum Populations in Regions of Malaria Endemicity in Vietnam from 2009 to 2016

Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4) [Peer Reviewed Journal]

Copyright © 2017 Thuy-Nhien et al. ;Copyright © 2017 Thuy-Nhien et al. 2017 Thuy-Nhien et al. ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/aac.01578-16 ;PMID: 28137815

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Title:
K13 Propeller Mutations in Plasmodium falciparum Populations in Regions of Malaria Endemicity in Vietnam from 2009 to 2016
Author: Thuy-Nhien, Nguyen ; Tuyen, Nguyen Kim ; Tong, Nguyen Thanh ; Vy, Nguyen Tuong ; Thanh, Ngo Viet ; Van, Huynh Thuy ; Huong-Thu, Pham ; Quang, Huynh Hong ; Boni, Maciej F ; Dolecek, Christiane ; Farrar, Jeremy ; Thwaites, Guy E ; Miotto, Olivo ; White, Nicholas J ; Hien, Tran Tinh
Subjects: Alleles ; Antimalarials - pharmacology ; Artemisinins - pharmacology ; Clinical Trials as Topic ; Drug Combinations ; Endemic Diseases ; Epidemiological Monitoring ; Epidemiology and Surveillance ; Erythrocytes - drug effects ; Erythrocytes - parasitology ; Gene Expression ; Gene Frequency ; Haplotypes ; Humans ; Malaria, Falciparum ; Malaria, Falciparum - drug therapy ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - parasitology ; Mutation ; Parasitemia ; Parasitemia - drug therapy ; Parasitemia - epidemiology ; Parasitemia - parasitology ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - genetics ; Protozoan Proteins ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Quinolines - pharmacology ; Vietnam - epidemiology
Is Part Of: Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4)
Description: The spread of artemisinin-resistant compromises the therapeutic efficacy of artemisinin combination therapies (ACTs) and is considered the greatest threat to current global initiatives to control and eliminate malaria. This is particularly relevant in Vietnam, where dihydroartemisinin-piperaquine (DP) is the recommended ACT for infection. The propeller domain gene of K13, a molecular marker of artemisinin resistance, was successfully sequenced in 1,060 isolates collected at 3 malaria hot spots in Vietnam between 2009 and 2016. Eight K13 propeller mutations (Thr474Ile, Tyr493His, Arg539Thr, Ile543Thr, Pro553Leu, Val568Gly, Pro574Leu, and Cys580Tyr), including several that have been validated to be artemisinin resistance markers, were found. The prevalences of K13 mutations were 29% (222/767), 6% (11/188), and 43% (45/105) in the Binh Phuoc, Ninh Thuan, and Gia Lai Provinces of Vietnam, respectively. Cys580Tyr became the dominant genotype in recent years, with 79.1% (34/43) of isolates in Binh Phuoc Province and 63% (17/27) of isolates in Gia Lai Province carrying this mutation. K13 mutations were associated with reduced ring-stage susceptibility to dihydroartemisinin (DHA) and prolonged parasite clearance An analysis of haplotypes flanking K13 suggested the presence of multiple strains with the Cys580Tyr mutation rather than a single strain expanding across the three sites.
Publisher: United States: American Society for Microbiology
Language: English
Identifier: ISSN: 0066-4804
EISSN: 1098-6596
DOI: 10.1128/aac.01578-16
PMID: 28137815
Source: MEDLINE
PubMed Central

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K13 Propeller Mutations in Plasmodium falciparum Populations in Regions of Malaria Endemicity in Vietnam from 2009 to 2016

Copyright © 2017 Thuy-Nhien et al. ;Copyright © 2017 Thuy-Nhien et al. 2017 Thuy-Nhien et al. ;ISSN: 0066-4804 ;EISSN: 1098-6596 ;DOI: 10.1128/aac.01578-16 ;PMID: 28137815

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