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Lipid Use and Misuse by the Heart

Circulation research, 2016-05, Vol.118 (11), p.1736-1751 [Peer Reviewed Journal]

2016 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.116.306842 ;PMID: 27230639

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  • Title:
    Lipid Use and Misuse by the Heart
  • Author: Schulze, P Christian ; Drosatos, Konstantinos ; Goldberg, Ira J
  • Subjects: Animals ; Diabetes Complications - metabolism ; Heart Diseases - etiology ; Heart Diseases - metabolism ; Humans ; Lipid Metabolism ; Myocardium - metabolism ; Oxidative Stress
  • Is Part Of: Circulation research, 2016-05, Vol.118 (11), p.1736-1751
  • Description: The heart utilizes large amounts of fatty acids as energy providing substrates. The physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids. Several processes that affect cardiac function, including ischemia, obesity, diabetes mellitus, sepsis, and most forms of heart failure lead to altered fatty acid oxidation and often also to the accumulation of lipids. There is now mounting evidence associating certain species of these lipids with cardiac lipotoxicity and subsequent myocardial dysfunction. Experimental and clinical data are discussed and paths to reduction of toxic lipids as a means to improve cardiac function are suggested.
  • Publisher: United States: American Heart Association, Inc
  • Language: English
  • Identifier: ISSN: 0009-7330
    EISSN: 1524-4571
    DOI: 10.1161/CIRCRESAHA.116.306842
    PMID: 27230639
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
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