Language:

Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage

Journal of neurology, neurosurgery and psychiatry, 2016-11, Vol.87 (11), p.1169-1173 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. ;Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2016-313653 ;PMID: 27466360 ;CODEN: JNNPAU

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage
Author: Murthy, Santosh B ; Urday, Sebastian ; Beslow, Lauren A ; Dawson, Jesse ; Lees, Kennedy ; Kimberly, W Taylor ; Iadecola, Costantino ; Kamel, Hooman ; Hanley, Daniel F ; Sheth, Kevin N ; Ziai, Wendy C
Subjects: Aged ; Blood pressure ; Brain Edema - diagnostic imaging ; Brain Edema - mortality ; Cerebral Hemorrhage - diagnostic imaging ; Cerebral Hemorrhage - mortality ; Cerebral Hemorrhage - therapy ; Clinical trials ; Disability Evaluation ; Disease Progression ; Edema ; Expansion ; Female ; Growth rate ; Hematoma - diagnostic imaging ; Hematoma - mortality ; Hospital Mortality ; Humans ; Male ; Measurement techniques ; Medical imaging ; Middle Aged ; Mortality ; Multivariate Analysis ; Outcome Assessment, Health Care ; Patients ; Predictive Value of Tests ; ROC Curve ; Stroke ; Studies ; Tomography, X-Ray Computed ; Variables
Is Part Of: Journal of neurology, neurosurgery and psychiatry, 2016-11, Vol.87 (11), p.1169-1173
Description: BackgroundPerihaematomal edema (PHE) expansion rate may be a predictor of outcome after intracerebral haemorrhage (ICH). We determined whether PHE expansion rate in the first 72 hours after ICH predicts outcome, and how it compares against other PHE measures.MethodsWe included patients from the Virtual International Stroke Trials Archive. We calculated PHE expansion rate using the equation: (PHE at 72 hours PHE at baseline)/(time to 72-hour CT scan time to baseline CT scan). Outcomes of interest were mortality and poor 90-day outcome (modified Rankin Scale score of ≥3). Logistic regression was used to assess relationships with outcome.ResultsA total of 596 patients with ICH were included. At baseline, median haematoma volume was 15.0 mL (IQR 7.9–29.2) with median PHE volume of 8.7 mL (IQR 4.5–15.5). Median PHE expansion rate was 0.31 mL/hour (IQR 0.12–0.55). The odds of mortality were greater with increasing PHE expansion rate (OR 2.63, CI 1.10 to 6.25), while the odds of poor outcome also increased with greater PHE growth (OR 1.67, CI 1.28 to 2.39). Female sex had an inverse relationship with PHE growth, but baseline haematoma volume had a direct correlation. Among other PHE measures, only interval increase in PHE correlated with poor outcome. There was no significant difference between the 2 measures of PHE volume expansion.ConclusionsRate of PHE growth over 72 hours was an independent predictor of mortality and poor functional outcomes following ICH. Baseline haematoma volume and gender appear to influence PHE growth.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0022-3050
EISSN: 1468-330X
DOI: 10.1136/jnnp-2016-313653
PMID: 27466360
CODEN: JNNPAU
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage

Searching Remote Databases, Please Wait