Language:

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

Archives of Toxicology. Archiv für Toxikologie, 2017-01, Vol.91 (1), p.35-61 [Peer Reviewed Journal]

The Author(s) 2016 ;Archives of Toxicology is a copyright of Springer, 2017. ;ISSN: 0340-5761 ;EISSN: 1432-0738 ;DOI: 10.1007/s00204-016-1733-8 ;PMID: 27209488

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment
Author: Nielsen, Gunnar Damgård ; Larsen, Søren Thor ; Wolkoff, Peder
Subjects: Air Pollutants - analysis ; Air Pollutants - metabolism ; Air Pollutants - toxicity ; Air Pollution, Indoor - adverse effects ; Air Pollution, Indoor - prevention & control ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Carcinogens, Environmental - analysis ; Carcinogens, Environmental - metabolism ; Carcinogens, Environmental - toxicity ; Disinfectants - analysis ; Disinfectants - metabolism ; Disinfectants - toxicity ; Environmental Health ; Formaldehyde - analysis ; Formaldehyde - metabolism ; Formaldehyde - toxicity ; Global Health ; Guidelines as Topic ; Health risk assessment ; Humans ; Indoor air quality ; Inhalation Exposure - adverse effects ; Inhalation Exposure - prevention & control ; Inhalation Exposure - standards ; Mutagens - analysis ; Mutagens - metabolism ; Mutagens - toxicity ; Neoplasms - chemically induced ; Neoplasms - epidemiology ; Neoplasms - prevention & control ; Occupational Medicine/Industrial Medicine ; Organizations ; Oxidative Stress - drug effects ; Pharmacology/Toxicology ; Public health ; Respiratory Tract Neoplasms - chemically induced ; Respiratory Tract Neoplasms - epidemiology ; Respiratory Tract Neoplasms - prevention & control ; Review ; Review Article ; Risk Assessment ; Toxicokinetics ; World Health Organization
Is Part Of: Archives of Toxicology. Archiv für Toxikologie, 2017-01, Vol.91 (1), p.35-61
Description: In 2010, the World Health Organization (WHO) established an indoor air quality guideline for short- and long-term exposures to formaldehyde (FA) of 0.1 mg/m 3 (0.08 ppm) for all 30-min periods at lifelong exposure. This guideline was supported by studies from 2010 to 2013. Since 2013, new key studies have been published and key cancer cohorts have been updated, which we have evaluated and compared with the WHO guideline. FA is genotoxic, causing DNA adduct formation, and has a clastogenic effect; exposure–response relationships were nonlinear. Relevant genetic polymorphisms were not identified. Normal indoor air FA concentrations do not pass beyond the respiratory epithelium, and therefore FA’s direct effects are limited to portal-of-entry effects. However, systemic effects have been observed in rats and mice, which may be due to secondary effects as airway inflammation and (sensory) irritation of eyes and the upper airways, which inter alia decreases respiratory ventilation. Both secondary effects are prevented at the guideline level. Nasopharyngeal cancer and leukaemia were observed inconsistently among studies; new updates of the US National Cancer Institute (NCI) cohort confirmed that the relative risk was not increased with mean FA exposures below 1 ppm and peak exposures below 4 ppm. Hodgkin’s lymphoma, not observed in the other studies reviewed and not considered FA dependent, was increased in the NCI cohort at a mean concentration ≥0.6 mg/m 3 and at peak exposures ≥2.5 mg/m 3 ; both levels are above the WHO guideline. Overall, the credibility of the WHO guideline has not been challenged by new studies.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0340-5761
EISSN: 1432-0738
DOI: 10.1007/s00204-016-1733-8
PMID: 27209488
Source: MEDLINE
ProQuest Central
Springer Nature OA Free Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment

The Author(s) 2016 ;Archives of Toxicology is a copyright of Springer, 2017. ;ISSN: 0340-5761 ;EISSN: 1432-0738 ;DOI: 10.1007/s00204-016-1733-8 ;PMID: 27209488

Searching Remote Databases, Please Wait