skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

HMGB1, IL-1α, IL-33 and S100 proteins： dual-function alarmins

Cellular & molecular immunology, 2017-01, Vol.14 (1), p.43-64 [Peer Reviewed Journal]

Copyright © 2017 The Author(s) 2017 The Author(s) ;ISSN: 1672-7681 ;EISSN: 2042-0226 ;DOI: 10.1038/cmi.2016.34 ;PMID: 27569562

Full text available

Citations Cited by
  • Title:
    HMGB1, IL-1α, IL-33 and S100 proteins： dual-function alarmins
  • Author: Bertheloot, Damien ; Latz, Eicke
  • Subjects: Alarmins - metabolism ; Animals ; HMGB1 ; HMGB1 Protein - metabolism ; Humans ; IL-1α ; Interleukin-1alpha - metabolism ; Interleukin-33 - metabolism ; Models, Biological ; Review ; S100 Proteins - metabolism ; S100蛋白 ; 免疫系统 ; 快速检测 ; 生殖细胞 ; 组织损伤 ; 细胞死亡
  • Is Part Of: Cellular & molecular immunology, 2017-01, Vol.14 (1), p.43-64
  • Description: Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein （HMGB1）, interleukin （IL）-1α, IL-33 and the Ca^2＋-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.
  • Publisher: China: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1672-7681
    EISSN: 2042-0226
    DOI: 10.1038/cmi.2016.34
    PMID: 27569562
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait