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Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?

The Journal of experimental medicine, 2016-07, Vol.213 (8), p.1375-1385 [Peer Reviewed Journal]

2016 Stanley et al. ;2016 Stanley et al. 2016 ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20160493 ;PMID: 27432942

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Title:
Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?
Author: Stanley, Molly ; Macauley, Shannon L ; Holtzman, David M
Subjects: Alzheimer Disease - drug therapy ; Alzheimer Disease - etiology ; Alzheimer Disease - metabolism ; Amyloid beta-Peptides - metabolism ; Diabetes Complications - drug therapy ; Diabetes Complications - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Humans ; Insulin - therapeutic use ; Insulin Resistance ; Reviews ; Signal Transduction - drug effects ; tau Proteins - metabolism
Is Part Of: The Journal of experimental medicine, 2016-07, Vol.213 (8), p.1375-1385
Description: Individuals with type 2 diabetes have an increased risk for developing Alzheimer's disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain. Moreover, oligomers/fibrils of amyloid-β (Aβ) can lead to neuronal insulin resistance and intranasal insulin is being explored as a potential therapy for AD. Conversely, elevated insulin levels (ins) are found in AD patients and high insulin has been reported to increase Aβ levels and tau phosphorylation, which could exacerbate AD pathology. Herein, we explore whether changes in ins and IS are a cause or consequence of AD.
Publisher: United States: The Rockefeller University Press
Language: English
Identifier: ISSN: 0022-1007
EISSN: 1540-9538
DOI: 10.1084/jem.20160493
PMID: 27432942
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?

2016 Stanley et al. ;2016 Stanley et al. 2016 ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20160493 ;PMID: 27432942

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