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Gr/gr deletions on Y-chromosome correlate with male infertility: an original study, meta-analyses, and trial sequential analyses

Scientific reports, 2016-02, Vol.6 (1), p.19798-19798, Article 19798 [Peer Reviewed Journal]

Copyright Nature Publishing Group Feb 2016 ;Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep19798 ;PMID: 26876364

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Title:
Gr/gr deletions on Y-chromosome correlate with male infertility: an original study, meta-analyses, and trial sequential analyses
Author: Bansal, Sandeep Kumar ; Jaiswal, Deepika ; Gupta, Nishi ; Singh, Kiran ; Dada, Rima ; Sankhwar, Satya Narayan ; Gupta, Gopal ; Rajender, Singh
Subjects: Adult ; Base Sequence ; Case-Control Studies ; Chromosomes, Human, Y - chemistry ; Continental Population Groups ; Fertility - genetics ; Haplotypes ; Humans ; Infertility ; Infertility, Male - ethnology ; Infertility, Male - genetics ; Infertility, Male - physiopathology ; Male ; Middle Aged ; Sequence Deletion ; Sperm ; Sperm Count ; Spermatogenesis - genetics ; Statistical analysis ; Y chromosomes
Is Part Of: Scientific reports, 2016-02, Vol.6 (1), p.19798-19798, Article 19798
Description: We analyzed the AZFc region of the Y-chromosome for complete (b2/b4) and distinct partial deletions (gr/gr, b1/b3, b2/b3) in 822 infertile and 225 proven fertile men. We observed complete AZFc deletions in 0.97% and partial deletions in 6.20% of the cases. Among partial deletions, the frequency of gr/gr deletions was the highest (5.84%). The comparison of partial deletion data between cases and controls suggested a significant association of the gr/gr deletions with infertility (P = 0.0004); however, the other partial deletions did not correlate with infertility. In cohort analysis, men with gr/gr deletions had a relatively poor sperm count (54.20 ± 57.45 million/ml) in comparison to those without deletions (72.49 ± 60.06), though the difference was not statistically significant (p = 0.071). Meta-analysis also suggested that gr/gr deletions are significantly associated with male infertility risk (OR = 1.821, 95% CI = 1.39-2.37, p = 0.000). We also performed trial sequential analyses that strengthened the evidence for an overall significant association of gr/gr deletions with the risk of male infertility. Another meta-analysis suggested a significant association of the gr/gr deletions with low sperm count. In conclusion, the gr/gr deletions show a strong correlation with male infertility risk and low sperm count, particularly in the Caucasian populations.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep19798
PMID: 26876364
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Gr/gr deletions on Y-chromosome correlate with male infertility: an original study, meta-analyses, and trial sequential analyses

Copyright Nature Publishing Group Feb 2016 ;Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep19798 ;PMID: 26876364

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