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Outcomes After Kidney injury in Surgery (OAKS): protocol for a multicentre, observational cohort study of acute kidney injury following major gastrointestinal and liver surgery

BMJ open, 2016-01, Vol.6 (1), p.e009812-e009812 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2016 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ 2016 ;ISSN: 2044-6055 ;EISSN: 2044-6055 ;DOI: 10.1136/bmjopen-2015-009812 ;PMID: 26769786

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Title:
Outcomes After Kidney injury in Surgery (OAKS): protocol for a multicentre, observational cohort study of acute kidney injury following major gastrointestinal and liver surgery
Subjects: Acute Kidney Injury - diagnosis ; Acute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Acute Kidney Injury - therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Audits ; Clinical Audit ; Clinical Protocols ; Clinical trials ; Collaboration ; Data collection ; Digestive System Surgical Procedures ; Female ; Follow-Up Studies ; Gastrointestinal surgery ; Humans ; Incidence ; Ireland ; Kidney diseases ; Laparoscopy ; Liver ; Logistic Models ; Male ; Middle Aged ; Morbidity ; Mortality ; Ostomy ; Outcome Assessment, Health Care ; Patients ; Postoperative Complications - diagnosis ; Postoperative Complications - epidemiology ; Postoperative Complications - therapy ; Prospective Studies ; Quality ; Sepsis ; Students ; Studies ; Surgeons ; Surgery ; United Kingdom ; Young Adult
Is Part Of: BMJ open, 2016-01, Vol.6 (1), p.e009812-e009812
Description: IntroductionAcute kidney injury (AKI) is associated with increased morbidity and mortality following cardiac surgery. Data focusing on the patterns of AKI following major gastrointestinal surgery could inform quality improvement projects and clinical trials, but there is a lack of reliable evidence. This multicentre study aims to determine the incidence and impact of AKI following major gastrointestinal and liver surgery.Methods and analysisThis prospective, collaborative, multicentre cohort study will include consecutive adults undergoing gastrointestinal resection, liver resection or reversal of ileostomy or colostomy. Open and laparoscopic procedures in elective and emergency patients will be included in the study. The primary end point will be the incidence of AKI within 7 days of surgery, identified using an adaptation of the National Algorithm for Detecting Acute Kidney Injury, which is based on the Kidney Disease Improving Global Outcomes (KDIGO) AKI guidelines. Secondary outcomes will include persistent renal dysfunction at discharge and 1 year postoperatively. The 30-day adverse event rate will be measured using the Clavien-Dindo scale. Data on factors that may predispose to the development of AKI will be collected to identify variables associated with AKI. Based on our previous collaborative studies, a minimum of 114 centres are expected to be recruited, contributing over 6500 patients in total.Ethics and disseminationThis study will be registered as clinical audit at each participating hospital. The protocol will be disseminated through local and national medical student networks in the UK and Ireland.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 2044-6055
EISSN: 2044-6055
DOI: 10.1136/bmjopen-2015-009812
PMID: 26769786
Source: ProQuest One Psychology
BMJ Open Access Journals
AUTh Library subscriptions: ProQuest Central
GFMER Free Medical Journals
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
DOAJ Directory of Open Access Journals

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Outcomes After Kidney injury in Surgery (OAKS): protocol for a multicentre, observational cohort study of acute kidney injury following major gastrointestinal and liver surgery

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