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The role of sex hormones in immune protection of the female reproductive tract

Nature reviews. Immunology, 2015-04, Vol.15 (4), p.217-230 [Peer Reviewed Journal]

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Apr 2015 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri3819 ;PMID: 25743222

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Title:
The role of sex hormones in immune protection of the female reproductive tract
Author: Wira, Charles R ; Rodriguez-Garcia, Marta ; Patel, Mickey V
Subjects: Analysis ; Animals ; Care and treatment ; Diagnosis ; Endocrine System - physiology ; Epithelial Cells - metabolism ; Female ; Fibroblasts - metabolism ; Genitalia, Female - cytology ; Genitalia, Female - immunology ; Genitalia, Female - metabolism ; Gonadal Steroid Hormones - metabolism ; Hormones, Sex ; Humans ; Immune system ; Menstrual Cycle - metabolism ; Mucous Membrane - immunology ; Mucous Membrane - metabolism ; Ovarian cancer ; Physiological aspects ; Pregnancy
Is Part Of: Nature reviews. Immunology, 2015-04, Vol.15 (4), p.217-230
Description: Within the human female reproductive tract (FRT), the challenge of protection against sexually transmitted infections (STIs) is coupled with the need to enable successful reproduction. Oestradiol and progesterone, which are secreted during the menstrual cycle, affect epithelial cells, fibroblasts and immune cells in the FRT to modify their functions and hence the individual's susceptibility to STIs in ways that are unique to specific sites in the FRT. The innate and adaptive immune systems are under hormonal control, and immune protection in the FRT varies with the phase of the menstrual cycle. Immune protection is dampened during the secretory phase of the cycle to optimize conditions for fertilization and pregnancy, which creates a 'window of vulnerability' during which potential pathogens can enter and infect the FRT.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/nri3819
PMID: 25743222
Source: MEDLINE
ProQuest Central

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The role of sex hormones in immune protection of the female reproductive tract

COPYRIGHT 2015 Nature Publishing Group ;COPYRIGHT 2015 Nature Publishing Group ;Copyright Nature Publishing Group Apr 2015 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri3819 ;PMID: 25743222

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