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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Gut, 2015-11, Vol.64 (11), p.1744-1754 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2015 ;ISSN: 0017-5749 ;EISSN: 1468-3288 ;DOI: 10.1136/gutjnl-2014-307913 ;PMID: 25500202 ;CODEN: GUTTAK

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Title:
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Author: Chambers, Edward S ; Viardot, Alexander ; Psichas, Arianna ; Morrison, Douglas J ; Murphy, Kevin G ; Zac-Varghese, Sagen E K ; MacDougall, Kenneth ; Preston, Tom ; Tedford, Catriona ; Finlayson, Graham S ; Blundell, John E ; Bell, Jimmy D ; Thomas, E Louise ; Mt-Isa, Shahrul ; Ashby, Deborah ; Gibson, Glen R ; Kolida, Sofia ; Dhillo, Waljit S ; Bloom, Stephen R ; Morley, Wayne ; Clegg, Stuart ; Frost, Gary
Subjects: Adiposity - drug effects ; Appetite Regulation - drug effects ; Biomedical research ; Body Weight Maintenance - drug effects ; Cells, Cultured ; Colon - cytology ; Colon - metabolism ; Cross-Over Studies ; Diet ; Double-Blind Method ; Fatty acids ; Female ; Fermentation ; Funding ; Glucagon-Like Peptide 1 - metabolism ; Gut Microbiota ; Hormones ; Humans ; Male ; Middle Aged ; Obesity ; Overweight - drug therapy ; Peptide YY - metabolism ; Peptides ; Propionates - administration & dosage ; Propionates - pharmacology ; Public health ; Transplants & implants ; Weight control
Is Part Of: Gut, 2015-11, Vol.64 (11), p.1744-1754
Description: ObjectiveThe colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.DesignTo investigate whether propionate promotes PYY and GLP-1 secretion, a primary cultured human colonic cell model was developed. To deliver propionate specifically to the colon, we developed a novel inulin-propionate ester. An acute randomised, controlled cross-over study was used to assess the effects of this inulin-propionate ester on energy intake and plasma PYY and GLP-1 concentrations. The long-term effects of inulin-propionate ester on weight gain were subsequently assessed in a randomised, controlled 24-week study involving 60 overweight adults.ResultsPropionate significantly stimulated the release of PYY and GLP-1 from human colonic cells. Acute ingestion of 10 g inulin-propionate ester significantly increased postprandial plasma PYY and GLP-1 and reduced energy intake. Over 24 weeks, 10 g/day inulin-propionate ester supplementation significantly reduced weight gain, intra-abdominal adipose tissue distribution, intrahepatocellular lipid content and prevented the deterioration in insulin sensitivity observed in the inulin-control group.ConclusionsThese data demonstrate for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.Trial registration numberNCT00750438.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0017-5749
EISSN: 1468-3288
DOI: 10.1136/gutjnl-2014-307913
PMID: 25500202
CODEN: GUTTAK
Source: BMJ Open Access Journals
MEDLINE
ProQuest Central

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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

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