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Increased male fertility using fertility-related biomarkers

Scientific reports, 2015-10, Vol.5 (1), p.15654-15654, Article 15654 [Peer Reviewed Journal]

Copyright Nature Publishing Group Oct 2015 ;Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep15654 ;PMID: 26489431

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Title:
Increased male fertility using fertility-related biomarkers
Author: Kwon, Woo-Sung ; Rahman, Md Saidur ; Ryu, Do-Yeal ; Park, Yoo-Jin ; Pang, Myung-Geol
Subjects: Animals ; Biomarkers ; Biomarkers - metabolism ; Capacitation ; Clinical trials ; Cytochrome ; Cytochrome b ; Fertility ; Fertility - genetics ; Fertilization ; Gene Expression Regulation ; Hogs ; Humans ; Infertility ; Infertility, Male - diagnosis ; Infertility, Male - genetics ; Infertility, Male - pathology ; Litter ; Male ; Protein Biosynthesis - genetics ; Proteins ; Proteomics ; Semen ; Semen - metabolism ; Semen Analysis ; Sperm ; Sperm Motility - genetics ; Spermatozoa - metabolism ; Spermatozoa - pathology ; Swine ; Tubulin
Is Part Of: Scientific reports, 2015-10, Vol.5 (1), p.15654-15654, Article 15654
Description: Conventional semen analyses are used to evaluate male factor fertility/infertility in humans and other animals. However, their clinical value remains controversial. Therefore, new tools that more accurately assess male fertility based on sperm function and fertilization mechanism are of interest worldwide. While protein markers in spermatozoa that might help differentiate fertile and infertile sperm have been identified, studies are in their infancy, and the markers require validation in field trials. In the present study, to discover more sensitive biomarkers in spermatozoa for predicting male fertility, we assessed protein expression in capacitated spermatozoa. The results demonstrated that cytochrome b-c1 complex subunit 2 (UQCRC2) was abundantly expressed in high-litter size spermatozoa (>3-fold). On the other hand, equatorin, beta-tubulin, cytochrome b-c1 complex subunit 1 (UQCRC1), speriolin, Ras-related protein Rab-2A (RAB2A), spermadhesin AQN-3, and seminal plasma sperm motility inhibitor were abundantly expressed in low-litter size spermatozoa (>3-fold). Moreover, RAB2A and UQCRC1 expression negatively correlated with litter size, while UQCRC2 expression positively correlated with litter size. Finally, the putative biomarkers predicted litter size in field trials. Our study suggests that biomarkers present in spermatozoa after capacitation can help differentiate superior male fertility from below-average fertility with high sensitivity.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep15654
PMID: 26489431
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Increased male fertility using fertility-related biomarkers

Copyright Nature Publishing Group Oct 2015 ;Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep15654 ;PMID: 26489431

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