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Physiologic implications of metal-ion transport by ZIP14 and ZIP8
Biometals, 2012-08, Vol.25 (4), p.643-655
[Peer Reviewed Journal]
Springer Science+Business Media, LLC. 2012 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-012-9526-x ;PMID: 22318508
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Title:
Physiologic implications of metal-ion transport by ZIP14 and ZIP8
Author:
Jenkitkasemwong, Supak
;
Wang, Chia-Yu
;
Mackenzie, Bryan
;
Knutson, Mitchell D.
Subjects:
Animals
;
Biochemistry
;
Biological Transport - genetics
;
Biological Transport - physiology
;
Biomedical and Life Sciences
;
Cadmium
;
Cadmium - metabolism
;
Cation Transport Proteins - chemistry
;
Cation Transport Proteins - genetics
;
Cation Transport Proteins - metabolism
;
Cell Biology
;
Epidemiology
;
Hemochromatosis - metabolism
;
Humans
;
Ions
;
Iron
;
Iron - metabolism
;
Life Sciences
;
Manganese
;
Manganese - metabolism
;
Medicine/Public Health
;
Metabolism
;
Metal ions
;
Metals
;
Microbiology
;
Pharmacology/Toxicology
;
Plant Physiology
;
Proteins
;
Trace elements
;
Transport
;
Zinc
;
Zinc - metabolism
Is Part Of:
Biometals, 2012-08, Vol.25 (4), p.643-655
Description:
Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural components of larger molecules that are indispensable for life. The three metal ions possess similar chemical properties and have been shown to compete for uptake in a variety of tissues, suggesting that they share common transport proteins. Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, manganese, and cadmium. Although knockout and transgenic mouse models are beginning to define the physiologic roles of ZIP14 and ZIP8 in the handling of zinc and cadmium, their roles in the metabolism of iron and manganese remain to be defined. Here we review similarities and differences in ZIP14 and ZIP8 in terms of structure, metal transport, tissue distribution, subcellular localization, and regulation. We also discuss potential roles of these proteins in the metabolism of zinc, iron, manganese, and cadmium as well as recent associations with human diseases.
Publisher:
Dordrecht: Springer Netherlands
Language:
English;Dutch
Identifier:
ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-012-9526-x
PMID: 22318508
Source:
MEDLINE
Alma/SFX Local Collection
ProQuest Central
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