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Sex-Specific Placental Responses in Fetal Development

Endocrinology (Philadelphia), 2015-10, Vol.156 (10), p.3422-3434 [Peer Reviewed Journal]

Copyright © 2015 by the Endocrine Society ;Copyright © 2015 by the Endocrine Society 2015 ;ISSN: 0013-7227 ;EISSN: 1945-7170 ;DOI: 10.1210/en.2015-1227 ;PMID: 26241064

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  • Title:
    Sex-Specific Placental Responses in Fetal Development
  • Author: Rosenfeld, Cheryl S
  • Subjects: Adult ; Animals ; Chorioallantoic Membrane - physiology ; Embryology ; Environmental Exposure ; Female ; Fetal Development - physiology ; Humans ; Male ; Mammals ; Maternal Exposure ; Maternal-Fetal Exchange ; Mice ; MicroRNAs - metabolism ; Minireviews ; Mutation ; Placenta - physiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Sex Characteristics ; Sex Factors ; Species Specificity
  • Is Part Of: Endocrinology (Philadelphia), 2015-10, Vol.156 (10), p.3422-3434
  • Description: The placenta is an ephemeral but critical organ for the survival of all eutherian mammals and marsupials. It is the primary messenger system between the mother and fetus, where communicational signals, nutrients, waste, gases, and extrinsic factors are exchanged. Although the placenta may buffer the fetus from various environmental insults, placental dysfunction might also contribute to detrimental developmental origins of adult health and disease effects. The placenta of one sex over the other might possess greater ability to respond and buffer against environmental insults. Given the potential role of the placenta in effecting the lifetime health of the offspring, it is not surprising that there has been a resurging interest in this organ, including the Human Placental Project launched by the National Institutes of Child Health and Human Development. In this review, we will compare embryological development of the laboratory mouse and human chorioallantoic placentae. Next, evidence that various species, including humans, exhibit normal sex-dependent structural and functional placental differences will be examined followed by how in utero environmental changes (nutritional state, stress, and exposure to environmental chemicals) might interact with fetal sex to affect this organ. Recent data also suggest that paternal state impacts placental function in a sex-dependent manner. The research to date linking placental maladaptive responses and later developmental origins of adult health and disease effects will be explored. Finally, we will focus on how sex chromosomes and epimutations may contribute to sex-dependent differences in placental function, the unanswered questions, and future directions that warrant further consideration.
  • Publisher: United States: Endocrine Society
  • Language: English
  • Identifier: ISSN: 0013-7227
    EISSN: 1945-7170
    DOI: 10.1210/en.2015-1227
    PMID: 26241064
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
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