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Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects

Neuropsychopharmacology (New York, N.Y.), 2015-10, Vol.40 (11), p.2536-2545 [Peer Reviewed Journal]

Copyright Nature Publishing Group Oct 2015 ;Copyright © 2015 American College of Neuropsychopharmacology 2015 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2015.100 ;PMID: 25865929 ;CODEN: NEROEW

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Title:
Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects
Author: Ito, Wataru ; Erisir, Alev ; Morozov, Alexei
Subjects: Animals ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Basolateral Nuclear Complex - drug effects ; Basolateral Nuclear Complex - physiopathology ; Disease Models, Animal ; Electroshock ; Fear - drug effects ; Fear - physiology ; Glutamic Acid - metabolism ; Ketamine - pharmacology ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Neural Pathways - drug effects ; Neural Pathways - physiopathology ; Original ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiopathology ; Psychotropic Drugs - pharmacology ; Receptors, AMPA - metabolism ; Receptors, N-Methyl-D-Aspartate - metabolism ; Stress, Psychological - drug therapy ; Stress, Psychological - physiopathology ; Synapses - drug effects ; Synapses - physiology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Tissue Culture Techniques ; Visual Perception
Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2015-10, Vol.40 (11), p.2536-2545
Description: Witnessing pain and distress in others can cause psychological trauma and increase odds of developing PTSD in the future, on exposure to another stressful event. However, the underlying synaptic process remains unknown. Here we report that mice exposed to a conspecific receiving electrical footshocks exhibited enhanced passive avoidance (PA) learning when trained 24 h after the exposure. The exposure activated neurons in the dorsomedial prefrontal cortex (dmPFC) and basolateral amygdala (BLA) and altered synaptic transmission from dmPFC to BLA. It increased amplitude, slowed decay of NMDA receptor-mediated currents, and generated silent synapses. Administration of sub-anesthetic ketamine immediately after the exposure prevented the enhancement of PA learning and silent synapse formation. These findings suggest that ketamine can prevent pathophysiological consequences of psychological trauma.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0893-133X
EISSN: 1740-634X
DOI: 10.1038/npp.2015.100
PMID: 25865929
CODEN: NEROEW
Source: ProQuest One Psychology
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central

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Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects

Copyright Nature Publishing Group Oct 2015 ;Copyright © 2015 American College of Neuropsychopharmacology 2015 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2015.100 ;PMID: 25865929 ;CODEN: NEROEW

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