Language:

Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography

NeuroImage (Orlando, Fla.), 2014-08, Vol.96, p.326-333 [Peer Reviewed Journal]

2014 Elsevier Inc. ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Aug 1, 2014 ;2014 Elsevier Inc. All rights reserved. 2014 ;ISSN: 1053-8119 ;EISSN: 1095-9572 ;DOI: 10.1016/j.neuroimage.2014.03.022 ;PMID: 24650603

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography
Author: Takahashi, Emi ; Hayashi, Emiko ; Schmahmann, Jeremy D. ; Ellen Grant, P.
Subjects: Attention deficit hyperactivity disorder ; Biological and medical sciences ; Brain ; Brain research ; Cell adhesion & migration ; Cerebellum ; Cerebellum - anatomy & histology ; Cerebellum - embryology ; Cerebellum - growth & development ; Development ; Dietary fiber ; Diffusion ; Diffusion imaging ; Diffusion Tensor Imaging - methods ; Female ; Fundamental and applied biological sciences. Psychology ; Human fetus ; Humans ; Image Enhancement - methods ; Male ; Nerve Fibers, Myelinated - physiology ; Nerve Fibers, Myelinated - ultrastructure ; Prenatal Diagnosis - methods ; Reproducibility of Results ; Sensitivity and Specificity ; Studies ; Tractography ; Vertebrates: nervous system and sense organs ; Womens health
Is Part Of: NeuroImage (Orlando, Fla.), 2014-08, Vol.96, p.326-333
Description: High angular resolution diffusion imaging (HARDI) tractography has provided insights into major white matter pathways and cortical development in the human fetal cerebrum. Our objective in this study was to further apply HARDI tracography to the developing human cerebellum ranging from fetal to adult stages, to outline in broad strokes the 3-dimensional development of white matter and local gray matter organization in the cerebellum. We imaged intact fixed fetal cerebellum specimens at 17 gestational weeks (W), 21W, 31W, 36W, and 38W along with an adult cerebellum for comparison. At the earliest gestational age studied (17W), coherent pathways that formed the superior, middle, and inferior cerebellar peduncles were already detected, but pathways between deep cerebellar nuclei and the cortex were not observed until after 38W. At 36–38W, we identified emerging regional specification of the middle cerebellar peduncle. In the cerebellar cortex, we observed disappearance of radial organization in the sagittal orientation during the studied developmental stages similar to our previous observations in developing cerebral cortex. In contrast, in the axial orientation, cerebellar cortical pathways emerged first sparsely (31W) and then with increased prominence at 36–38W with pathways detected both in the radial and tangential directions to the cortical surface. The cerebellar vermis first contained only pathways tangential to the long axes of folia (17–21W), but pathways parallel to the long axes of folia emerged between 21 and 31W. Our results show the potential for HARDI tractography to image developing human cerebellar connectivity. •Regional specification of middle cerebellar peduncle was emerged at late preterm.•In cerebellar cortex, radial coherence disappeared before birth in sagittal planes.•In axial planes, cerebellar cortical pathways gradually emerged after mid preterm.•In vermis, first tangential pathways were observed followed by parallel pathways.
Publisher: Amsterdam: Elsevier Inc
Language: English
Identifier: ISSN: 1053-8119
EISSN: 1095-9572
DOI: 10.1016/j.neuroimage.2014.03.022
PMID: 24650603
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography

2014 Elsevier Inc. ;2015 INIST-CNRS ;Copyright © 2014 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Aug 1, 2014 ;2014 Elsevier Inc. All rights reserved. 2014 ;ISSN: 1053-8119 ;EISSN: 1095-9572 ;DOI: 10.1016/j.neuroimage.2014.03.022 ;PMID: 24650603

Searching Remote Databases, Please Wait