Language:

Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives

Journal of psychiatry & neuroscience, 2014-09, Vol.39 (5), p.304-311 [Peer Reviewed Journal]

Canadian Medical Association ;COPYRIGHT 2014 Joule Inc. ;Copyright Canadian Medical Association Sep 2014 ;2014 Canadian Medical Association 2014 ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1503/jpn.130220 ;PMID: 24866415 ;CODEN: JPNEEF

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives
Author: Hou, Jing-Ming, MD ; Zhao, Ming, MM ; Zhang, Wei, MM ; Song, Ling-Heng, MM ; Wu, Wen-Jing, MM ; Wang, Jian, MD, PhD ; Zhou, Dai-Quan, PhD ; Xie, Bing, MD, PhD ; He, Mei, PhD ; Guo, Jun-Wei, MM ; Qu, Wei, MD, PhD ; Li, Hai-Tao, MD, PhD
Subjects: Adult ; Anxieties ; Brain - physiopathology ; Brain Mapping ; Comorbidity ; Endophenotypes ; Family ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Medical Education ; Mental depression ; Methods ; Neural Pathways - physiopathology ; Obsessive compulsive disorder ; Obsessive-Compulsive Disorder - drug therapy ; Obsessive-Compulsive Disorder - epidemiology ; Obsessive-Compulsive Disorder - physiopathology ; Physiological aspects ; Psychiatry ; Research Papers ; Signal Processing, Computer-Assisted ; Teenagers
Is Part Of: Journal of psychiatry & neuroscience, 2014-09, Vol.39 (5), p.304-311
Description: Background Obsessive–compulsive disorder (OCD) is a common, heritable neuropsychiatric disorder, hypothetically underpinned by dysfunction of brain cortical-striatal-thalamic-cortical (CSTC) circuits; however, the extent of brain functional abnormalities in individuals with OCD is unclear, and the genetic basis of this disorder is poorly understood. We determined the whole brain functional connectivity patterns in patients with OCD and their healthy first-degree relatives. Methods We used resting-state fMRI to measure functional connectivity strength in patients with OCD, their healthy first-degree relatives and healthy controls. Whole brain functional networks were constructed by measuring the temporal correlations of all brain voxel pairs and further analyzed using a graph theory approach. Results We enrolled 39 patients with OCD, 20 healthy first-degree relatives and 39 healthy controls in our study. Compared with healthy controls, patients with OCD showed increased functional connectivity primarily within the CSTC circuits and decreased functional connectivity in the occipital cortex, temporal cortex and cerebellum. Moreover, patients with OCD and their first-degree relatives exhibited overlapping increased functional connectivity strength in the bilateral caudate nucleus, left orbitofrontal cortex (OFC) and left middle temporal gyrus. Limitations Potential confounding factors, such as medication use, heterogeneity in symptom clusters and comorbid disorders, may have impacted our findings. Conclusion Our preliminary results suggest that patients with OCD have abnormal resting-state functional connectivity that is not limited to CSTC circuits and involves abnormalities in additional large-scale brain systems, especially the limbic system. Moreover, resting-state functional connectivity strength abnormalities in the left OFC, bilateral caudate nucleus and left middle temporal gyrus may be neuroimaging endophenotypes for OCD.
Publisher: Canada: Joule Inc
Language: French;English
Identifier: ISSN: 1180-4882
EISSN: 1488-2434
DOI: 10.1503/jpn.130220
PMID: 24866415
CODEN: JPNEEF
Source: ProQuest One Psychology
Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives

Canadian Medical Association ;COPYRIGHT 2014 Joule Inc. ;Copyright Canadian Medical Association Sep 2014 ;2014 Canadian Medical Association 2014 ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1503/jpn.130220 ;PMID: 24866415 ;CODEN: JPNEEF

Searching Remote Databases, Please Wait